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Whitening Effect of Salvia miltorrhiza Bunge Water Extract in Human Epidermal Melanocyte
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 Title & Authors
Whitening Effect of Salvia miltorrhiza Bunge Water Extract in Human Epidermal Melanocyte
Park, Tae-Soon; Kim, Dong-Hee; Son, Jun-Ho;
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The objective of this study was to investigate the whitening effect of Salvia miltorrhiza Bunge water extract (SM-W) in human epidermal melanocyte (HEM). Mushroom tyrosinase inhibitory effect of SM-W was approximately 42% at . The HEM cellular tyrosinase and melanin synthesis inhibition activity were 26 and 25% at , respectively. Whitening related proteins and mRNAs including tyrosinase, tyrosinase related protein 1 (TRP-1) and TRP-2, and microphthalmia associated transcription factor were reduced by SM-W treatment. In addition, the cAMP expression inhibitory effect of SM-W was decreased by 41% at concentration. These results indicated that Salvia miltorrhiza Bunge could be used to the possible utilization of functional cosmetic ingredients by confirming whitening activity related with melanin content.
cosmetic;human epidermal melanocyte;Salvia miltorrhiza Bunge;tyrosinase;whitening;
 Cited by
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