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Pharmacokinetic Study of Florfenicol in Healthy and Vibriosis-infected Pseudosciaena crocea after Oral Administration
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 Title & Authors
Pharmacokinetic Study of Florfenicol in Healthy and Vibriosis-infected Pseudosciaena crocea after Oral Administration
Wang, Li; Han, Yan-nan; Jin, Shan; Ma, Yin; Wang, Guo-liang; Zhao, Qing-song; Chen, Yin-er;
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The pharmacokinetics of florfenicol were studied in healthy and vibriosis-infected large yellow croaker (Pseudosciaena crocea) following administration of a single oral dose of at . After oral administration, florfenicol levels in tissues (liver, kidney, muscle, serum, and skin) were analyzed using high-performance liquid chromatography. A two-compartment open model was used to describe the pharmacokinetics of florfenicol following oral administration. Compared to the healthy group, the absorption rate of vibriosis-infected fish significantly decreased, peak-time () delayed, maximum concentration () declined, total body clearance decreased, the elimination half-life () was extended, and the area under the curve increased. These results indicate that a oral dose of florfenicol administered once daily continuously for 4 or 5 days can be used for the treatment of Vibrio alginolyticus infection in large yellow croaker (Pseudosciaena crocea).
florfenicol;pharmacokinetics;Pseudosciaena crocea;Vibrio alginolyticus;
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