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Some Monascus purpureus Genomes Lack the Monacolin K Biosynthesis Locus
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 Title & Authors
Some Monascus purpureus Genomes Lack the Monacolin K Biosynthesis Locus
Kwon, Hyung-Jin; Balakrishnan, Bijinu; Kim, Yeon-Ki;
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 Abstract
Two Monascus purpureus genomes lack the monacolin K biosynthesis locus (mok), while Monascus species are generally assumed to be monacolin K producers. These M. purpureus harbor a fusion of mokA and mokB orthologues. This finding suggests that an ancestral mok locus underwent a deletion event in the M. purpureus genome.
 Keywords
genome sequence;monacolin K biosynthetic gene cluster;Monascus purpureus;polyketide synthase gene;
 Language
English
 Cited by
1.
Alleviation of metabolic syndrome by monascin and ankaflavin: the perspective of Monascus functional foods, Food Funct., 2017, 8, 6, 2102  crossref(new windwow)
 References
1.
Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z, Miller W et al. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25, 3389-402. crossref(new window)

2.
Balakrishnan B, Chen CC, Pan TM, and Kwon HJ (2014) Mpp7 controls regioselective Knoevenagel condensation during the biosynthesis of Monascus azaphilone pigments. Tetrahedron Lett 55, 1640-3. crossref(new window)

3.
Balakrishnan B, Karki S, Chiu SH, Kim HJ, Suh JW, Nam B et al. (2013) Genetic localization and in vivo characterization of a Monascus azaphilone pigment biosynthetic gene cluster. Appl Microbiol Biotechnol 97, 6337-45. crossref(new window)

4.
Chen YP, Tseng CP, Chien IL, Wang WY, Liaw LL, and Yuan GF (2008a) Exploring the distribution of citrinin biosynthesis related genes among Monascus species. J Agric Food Chem 56, 11767-72. crossref(new window)

5.
Chen YP, Tseng CP, Liaw LL, Wang CL, Chen IC, Wu WJ et al. (2008b) Cloning and characterization of monacolin K biosynthetic gene cluster from Monascus pilosus. J Agric Food Chem 56, 5639-46. crossref(new window)

6.
Feng Y, Shao Y, and Chen F (2012) Monascus pigments. Appl Micorbiol Biotechnol 96, 1421-40. crossref(new window)

7.
Kennedy J, Auclair K, Kendrew SG, Park C, Vederas JC, and Hutchinson CR (1999) Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. Science 284, 1368-72. crossref(new window)

8.
Lee CL and Pan TM (2012) Development of Monascus fermentation technology for high hypolipidemic effect. Appl Microbiol Biotechnol 94, 1449-59. crossref(new window)

9.
Li YG, Zhang F, Wang ZT, and Hu ZB (2004) Identification and chemical profiling of monacolins in red yeast rice using high-performance liquid chromatography with photodiode array detector and mass spectrometry. J Pharm Biomed Anal 35, 1101-12. crossref(new window)

10.
Liu Q, Xie N, He Y, Wang L, Shao Y, Zhao H et al. (2014) MpigE, a gene involved in pigment biosynthesis in Monascus ruber M7. Appl Microbiol Biotechnol 98, 285-96. crossref(new window)

11.
Marchler-Bauer A, Derbyshire MK, Gonzales NR, Lu S, Chitsaz F, Geer LY et al. (2015) CDD: NCBI's conserved domain database. Nucleic Acids Res 43, D222-6. crossref(new window)

12.
Patakova P (2013) Monascus secondary metabolites: production and biological activity. J Ind Microbiol Biotechnol 40, 169-81. crossref(new window)

13.
Sakai K, Kinoshita H, Shimizu T, and Nihira T (2008) Construction of a citrinin gene cluster expression system in heterologous Aspergillus oryzae. J Biosci Bioeng 106, 466-72. crossref(new window)

14.
Shimizu T, Kinoshita H, and Nihira T (2007) Identification and in vivo functional analysis by gene disruption of ctnA, an activator gene involved in citrinin biosynthesis in Monascus purpureus. Appl Environ Microbiol 73, 5097-103. crossref(new window)

15.
Wang TH and Lin TF (2007) Monascus rice products. Adv Food Nutr Res 53, 123-59. crossref(new window)

16.
Yang Y, Liu B, Du X, Li P, Liang B, Cheng X et al. (2015) Complete genome sequence and transcriptomics analyses reveal pigment biosynthesis and regulatory mechanisms in an industrial strain, Monascus purpureus YY-1. Sci Rep 5:8331. crossref(new window)

17.
Yasuda M, Tachibana S, and Kuba-Miyara M (2012) Biochemical aspects of red koji and tofuyo prepared using Monascus fungi. Appl Microbiol Biotechnol 96, 49−60. crossref(new window)