Advanced SearchSearch Tips
Preventive effect of fermented red ginseng on cisplatin-induced nephrotoxicity mouse
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Preventive effect of fermented red ginseng on cisplatin-induced nephrotoxicity mouse
Hyun, Ja-Kyoung; Kwon, O Jun; Lee, Joo Young; Roh, Seong-Soo; Seo, Young-Bae;
  PDF(new window)
Red ginseng is known to have many beneficial effects. Cisplatin, an effective antineoplastic drug, can cause many side effects like irreversible sensorineural hearing loss and serious tinnitus in humans. This study is aimed to reduce a cisplatin`s side effect, nephrotoxicity by fermentated korean red ginseng. Korea ginseng was produced by steaming and dring and fermentation. And mice were divided into 4 groups- (A) normal mice, (B) Vehicle treated cisplatin mice, (C) RG0F0-treated cisplatin mice, (D) RG8F3-treated cisplatin mice. C and D groups were feed each material 200 mg/kg/day during 4 days. And cisplatin 20 mg/kg injected to B, C, and D groups as abdominal injection. After 24 h, blood sample was collected. The kidneys were harvested for histological, immuno histochemical and western blot analysis. 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2`-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity was depended on steaming hours. RG0F0 and RG8F3 (ginseng-8 h steamed and fermented by Saccharomyces cerevisiae) were showed antioxidants effect in DPPH and ABTS radical scavenging activity. Component amounts according to steaming hours. 8 h steamed red ginseng had the most ingredients of ginsenoside. Treatments with RG8F3 reduced cisplatin-induced nephrotoxicity in the mice resulting in increase of GSH and decrease of ROS, BUN, creatinine, and inflammatory mediators. This result seems to be involved with the restriction of the inflammation in the kidney. Therefore, fermented red ginseng might have therapeutic efficacy in reduce kidney injury induced by cisplatin treatment.
Anti-oxidation;Cisplatin;Fermentation;Nephrotoxicity;Red Ginseng;
 Cited by
Ahn DW, Kim SR, Ha DH, Kim SH (2007) Mechanism of Amelipration of Cisplatin Nephrotoxicity by Procaine Treatment in Mice. Korean J Anesthesiol 52: 318-327 crossref(new window)

Appenroth D, Frob S, Kersten L, Splinter FK, Winnefeld K (1997) Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing rats. Arch Toxicol 71: 677-683 crossref(new window)

Bae EA, Han MJ, Choo MK, Park SY, Kim DH (2002) Metabolism of 20(S)-and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biological & Pharmaceutical Bulletin 25: 58-63 crossref(new window)

Bae EA, Han MJ, Kim EJ, Kim DH (2004) Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants. Archives of pharmacal research 27: 61-67 crossref(new window)

Bae EA, Park SY, KIM DH (2000) Constitutive. BETA.-Glucosidases Hydrolyzing Ginsenoside Rb1 and Rb2 from Human Intestinal Bacteria. Biological and Pharmaceutical Bulletin 23: 1481-1485 crossref(new window)

Baek SH, Piao XL, Lee UJ, Kim HY, Park JH (2006) Reduction of cisplatin-induced nephrotoxicity by ginsenosides isolated from processed ginseng in cultured renal tubular cells. Biological and Pharmaceutical Bulletin 29: 2051-2055 crossref(new window)

Davis CA, Nick HS, Agarwal A (2001) Manganese superoxide dismutase attenuates cisplatin-induced renal injury: importance of superoxide. J Am Soc Nephrol 12: 2683-2690

Gandara DR, Perez EA, Phillips WA, Lawrence HJ, DeGregorio M (1989) Evaluation of cisplatin dose intensity: current status and future prospects. Anticancer Res 9: 1121-1128

Glover D, Grabelsky S, Fox K, Weiler C, Cannon L, Glick J (1989) Clinical trials of WR-2721 and cis-platinum. Int J Radiat Oncol Biol Phys 16: 1201-1204 crossref(new window)

Han SY, Yeo SH, Jeong ST, Choi HS, Baek SY, Park HY (2012) Status and Prospect of plant Fermented Liquid in Korea. Food Science and Industry 45: 31-43

Hasegawa H, Sung JH, Benno Y (1997) Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins. Planta medica 63: 436-440 crossref(new window)

Howell SB, Taetle R (1980) Effect of sodium thiosulfate on cisdichloro diammineplatinum (II) toxicity and antitumor activity in L1210 leukemia. Cancer Treat Rep 64: 611-616

Ju SM, Kim SH, Kim YM, Jeon BH, Kim WS (2013) Machanism of Cisplatin-induced Apoptosis and Bojungbangam-tang-mediated Anti-apoptotic Effect on Cell Proliferation in Rat Mesangial Cells. Korean J Oriental Physiology & Pathology 27: 43-48

Jung KW, Won YJ, Kong HJ, Oh CM, Cho HS, Lee DH, Lee KH (2015) Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012. Cancer Res Treat 47: 127-141 crossref(new window)

Kim DG, Kim KJ, Ju SM, Kim YI, Choi HS, Keum KS, Kim WS, Gao YA, Jeon BH (2003) Protective effect of Ganopoly and Ganopoly/C+ on nephrotoxicity induced by cisplatin in rats. Korean J Oriental Physiology & Pathology 17: 316-325

Kim HG, Kim KY, Cha CJ (2007) Screening for ginsengfermenting microoragnisms capable of biotransforming ginsenosides. Kor J Microbiol 43: 142-146

Kim HJ, Kwak IA, Kim HJ, Ahn JS, Son YB (2013) A Study on the Amendment Scheme of Ginsenoside Content Standard Regulation for Red Ginseng Products in Korea. Journal of Food Hygiene and Safety 28: 24-30 crossref(new window)

Kim HJ, Seo MH, Lee EK, Cho HE, Choi YH, Lee KN, Chong MS (2009) Effect of Fermented Red Ginseng Extracts on Physiological Activity and Blood Glucose Level in Streptozotocin Induced Diabetic Rats. Korean J Oriental Physiology & Pathology 23: 1087-1094

Kim JY, Kim CH (2014) Effect of Zizyphi Spinosae Extract on Cisplatin and t-Butylhydroperoxide Induced Acute Renal Failure in Rabbits. Journal of Life Science 24: 777-783 crossref(new window)

Krarup-Hansen A, Helweg-Larsen S, Schmalbruch H, Rorth M, Krarup C (2007) Neuronal involvement in cisplatin neuropathy: prospective clinical and neurophysiological studies. Brain 130: 1076-1088

Moncada S, Palmer RML, Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacological reviews 43: 109-142

Nam KY (2005) The Comoarative Understanding between Red Ginseng and White Ginsengs, Processed Ginsengs (Panax ginseng C.A. Meyer). J Ginseng Res 29: 1-18 crossref(new window)

Naziroglu M, Karaoglu A, Aksoy AO (2004) Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver, and lens tissues in rats. Toxicology 195: 221-230 crossref(new window)

Nicolao P, Giometto B (2003) Neurological toxicity of ifosfamide. Oncology 65: 11-16 crossref(new window)

Nishijo H, Uwano T, Zhong Y M, Ono T (2004). Proof of the mysterious efficacy of ginseng: basic and clinical trials: effects of red ginseng on learning and memory deficits in an animal model of amnesia. Journal of pharmacological sciences 95: 145-152 crossref(new window)

Oriana S, Bohm S, Spatti G, Zunino F, Di Re F (1987) A preliminary clinical experience with reduced glutathione as protector against cisplatin-toxicity. Tumori 73: 337-340 crossref(new window)

Ozols RF, Corden BJ, Jacob J, Wesley MN, Ostchega Y, Young RC (1984) High-dose cisplatin in hypertonic saline. Ann Intern Med 100: 19-24 crossref(new window)

Pabla N, Dong Z (2008) Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney international 73: 994-1007 crossref(new window)

Park CK, Jeon BS, Yang JW (2003) The Chemical Components of Korean Ginseng. Food Industry and Nutrition 8: 10-23

Park SY, Choung SY (1998) Inhibitory Effect of Schizandrin on Nephrotoxicity of Cisplatin. Korean J Environ. Toxicol 13: 125-131

Parlakpinar H, Sahna E, Ozer MK, Ozuglurlu F, Vardi N, Acet A (2002) Physiological and pharmacological concentrations of melatonin protect against cisplatin-induced acute renal injury. J Pineal Res 33: 161-166 crossref(new window)

Ramesh G, Reeves WB (2002) TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. Journal of Clinical Investigation 110: 835-842 crossref(new window)

Safirstein R, Miller P, Guttenplan JB (1984) Uptake and metabolism of cisplatin by rat kidney. Kidney Int 25: 753-8 crossref(new window)

Safirstein R, Winston J, Goldstein M, Moel D, Dikman S, Guttenplan J (1986) Cisplatin nephrotoxicity. American Journal of Kidney Diseases 8: 356-367 crossref(new window)

Storck M, Schilling M, Prestel R, Abendroth D, Burkhardt K, Hammer C (1994) Production of proinflammatory cytokines and adhesion molecules in exvivo xenogeneic kidney perfusion. Transplant International 7: 647-649 crossref(new window)

Sutton TA, Molitoris BA (1998) Mechanisms of cellular injury in ischemic acute renal failure. Seminars in Nephrology 18: 490-497

Yoon SS (2008) Management of Hematologic Malignancies. J Korean Oncol Nurs 8: 67-75