Prediction of Glucose Concentration in a Glucose-Lactose Mixture Based on the Reflective Optical Power at Dual Probe Wavelengths Gao, Song; Yue, Wenjing; Lee, Sang-Shin;
An enzyme-free optical method is proposed for estimating high concentrations of glucose in a glucose-lactose mixture, based on a predictive equation that takes advantage of the reflective optical power observed at two discrete wavelengths. Compared to the conventional absorption spectroscopy method based on Beer's Law, which is mainly valid for concentrations below hundreds of mg/dL, the proposed scheme, which relies on reflection signals, can be applied to measure higher glucose concentrations, of even several g/dL in a glucose-lactose mixture. Two probe wavelengths of 1160 and 1300 nm were selected to provide a linear relationship between the reflective power and pure glucose/lactose concentration, where the relevant linear coefficients were derived to complete the predictive equation. Glucose concentrations from 2 to 7 g/dL in a glucose-lactose mixture were efficiently estimated, using the established predictive equation based on monitored reflective powers. The standard error of prediction was 1.17 g/dL.
High glucose concentration;Correlation coefficient;Glucose-lactose mixture;Reflective optical power;
T. Sato, K. Katayama, T. Arai, T. Sako, and H. Tazaki, “Simultaneous determination of serum mannose and glucose concentrations in dog serum using high performance liquid chromatography,” Res. Vet. Sci. 84, 26-29 (2008).
G. P. Parpinello and A. Versari, “A simple high-performance liquid chromatography method for the analysis of glucose, glycerol, and methanol in a bioprocess,” J. Chromatogr. Sci. 38, 259-261 (2000).
J. P. Yuan and F. Chen, “Simultaneous separation and determination of sugars, ascorbic acid and furanic compounds by HPLC-dual detection,” Food Chem. 64, 423-427 (1999).
L. Setti, A. Fraleoni-Morgera, B. Ballarin, A. Filippini, D. Frascaro, and C. Piana, “An amperometric glucose biosensor prototype fabricated by thermal inkjet printing,” Biosens. Bioelectron. 20, 2019-2026 (2005).
M. D. Gouda, M. A. Kumar, M. S. Thakur, and N. G. Karanth, “Enhancement of operational stability of an enzyme biosensor for glucose and sucrose using protein based stabilizing agents,” Biosens. Bioelectron. 17, 503-507 (2002).
A. M. G. Vasilarou and C. A. Georgiou, “Enzymatic spectrophotometric reaction rate determination of glucose in fruit drinks and carbonated beverages. An analytical chemistry laboratory experiment for food science-oriented students,” J. Chem. Educ. 77, 1327-1329 (2000).
R. H. Matthews, P. R. Pehrsson, and M. Farhat-Sabet, Sugar Content of Selected Foods: Individual and Total Sugars (U.S. Department of Agriculture, Human Nutrition Information Service, USA, 1987).
B. A. A. Dremel, B. P. H. Schaffar, and R. D. Schmid, “Determination of glucose in wine and fruit juice based on fibre-optic glucose biosensor and flow-injection analysis,” Anal. Chim. Acta. 225, 293-301 (1989).
W. B. Martin, S. Mirov, and R. Venugopalan, “Using two discrete frequencies within the middle infrared to quantitatively determine glucose in serum,” J. Biomed. Opt. 7, 613-617 (2002).
M. Brandstetter, A. Genner, K. Anic, and B. Lendl, “Tunable external cavity quantum cascade laser for the simultaneous determinati on of glucose and lactate in aqueous phase,” Analyst 135, 3260-3265 (2010).
M. Meinke, G. Muller, H. Albrecht, C. Antoniou, H. Richter, and J. Lademann, "Two-wavelength carbon dioxide laser application for in-vitro blood glucose measurements," J. Biomed. Opt. 13, 014021 (2008).
S. Yu, D. Li, H. Chong, C. Sun, H. Yu, and K. Xu, “In vitro glucose measurement using tunable mid-infrared laser spectroscopy combined with fiber-optic sensor,” Biomed. Opt. Express 5, 275-286 (2014).
H. Fisher, R. G. Hansen, and H. W. Norton, “Quantitative determination of glucose and galactose,” Anal. Chem. 27, 857-859 (1955).
Y. Mendelson, A. C. Clermont, R. A. Peura, and B. C. Lin, “Blood glucose measurement by multiple attenuated total reflection and infrared absorption spectroscopy,” IEEE Trans. Biomed. Eng. 37, 458-465 (1990).
S. Nielsen, Food Analysis (Springer Science & Business Media, USA, 2010).
T. Katsu, X. Zhang, and G. A. Rechnitz, “Simultaneous determination of lactose and glucose in milk using two working enzyme electrodes,” Talanta 41, 843-848 (1994).
J. H. Rodriguez-Rodriguez, F. Martinez-Pinon, J. A. Alvarez-Chavez, D. Jaramillo-Vigueras, and E. G. Robles-Pimentel, "Direct optical techniques for the measurement of water content in oil-paper insulation in power transformers," Meas. Sci. Technol. 22, 065706 (2011).
R. M. Vogel, “The probability plot correlation coefficient test for the normal, lognormal, and gumbel distributional hypotheses,” Water Resour. Res. 22, 587-590 (1986).
K. H. Esbensen, D. Guyot, F. Westad, and L. P. Houmoller, Multivariate Data Analysis - In Practice: An Introduction to Multivariate Data Analysis and Experimental Design, 5th ed. (Multivariate Data Analysis, Denmark, 2002).
P. F. Fox, T. Uniacke-Lowe, P. L. H. McSweeney, and J. A. O'Mahony, Dairy Chemistry and Biochemistry, 2nd ed. (Springer, 2015).
P. L. H. McSweeney and P. F. Fox, Advanced Dairy Chemistry: Volume 3: Lactose, Water, Salts and Minor Constituents, 3rd ed. (Springer Science & Business Media, 2009).