JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Near-Infrared Laser Stimulation of the Auditory Nerve in Guinea Pigs
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Near-Infrared Laser Stimulation of the Auditory Nerve in Guinea Pigs
Guan, Tian; Wang, Jian; Yang, Muqun; Zhu, Kai; Wang, Yong; Nie, Guohui;
  PDF(new window)
 Abstract
This study has investigated the feasibility of 980-nm low-energy pulsed near-infrared laser stimulation to evoke auditory responses, as well as the effects of radiant exposure and pulse duration on auditory responses. In the experiments, a hole was drilled in the basal turn of the cochlea in guinea pigs. An optical fiber with a 980-nm pulsed infrared laser was inserted into the hole, orientating the spiral ganglion cells in the cochlea. To model deafness, the tympanic membrane was mechanically damaged. Acoustically evoked compound action potentials (ACAPs) were recorded before and after deafness, and optically evoked compound action potentials (OCAPs) were recorded after deafness. Similar spatial selectivity between optical and acoustical stimulation was found. In addition, OCAP amplitudes increased with radiant exposure, indicating a photothermal mechanism induced by optical stimulation. Furthermore, at a fixed radiant exposure, OCAP amplitudes decreased as pulse duration increased, suggesting that optical stimulation might be governed by the time duration over which the energy is delivered. Thus, the current experiments have demonstrated that a 980-nm pulsed near-infrared laser with low energy can evoke auditory neural responses similar to those evoked by acoustical stimulation. This approach could be used to develop optical cochlear implants.
 Keywords
Cochlear implant;Pulsed near-infrared laser;Optical stimulation;Optical compound action potential;
 Language
English
 Cited by
 References
1.
World Health Organization, Primary Ear and Hearing Care Training Resource, CD-ROM (Stylus Publishing, LLC, Sterling, VA, 2006).

2.
J. Wells, C. Kao, P. Konrad, A. M. Jansen, and E. D. Jansen, “Biophysical mechanisms responsible for pulsed low-level laser excitation of neural tissue,” Proc. SPIE 6084, 60840X (2006).

3.
A. D. Izzo, J. Pathria, E. Suh, J. T. Walsh, D. S. Whitlon, E. D. Jansen, and C. P. Richter, “Selectivity of optical stimulation in the auditory system,” Proc. SPIE 6078, 60781P (2006).

4.
A. D. Izzo, E. Suh, J. Pathria, J. T. Walsh, D. S. Whitlon, and C. P. Richter, “Selectivity of neural stimulation in the auditory system: a comparison of optic and electric stimuli,” J. Biomed. Opt. 12, 021008:1-7 (2007).

5.
C. P. Richter, A. I. Matic, J. D. Wells, E. D. Jansen, and J. T. Walsh, “Neural stimulation with optical radiation,” Laser Photon. Rev. 5, 68-80 (2011). crossref(new window)

6.
I. U. Teudt, A. E. Nevel, A. D. Izzo, J. T. Walsh, and C. P. Richter, “Optical stimulation of the facial nerve: a new monitoring technique?,” Laryngoscope 117, 1641-1647 (2007). crossref(new window)

7.
J. Wells, P. Konrad, C. Kao, E. D. Jansen, and A. Mahadevan-Jansen, “Pulsed laser versus electrical energy for peripheral nerve stimulation,” J. Neurosci. Methods 163, 326-337 (2007). crossref(new window)

8.
A. I. Matic, J. T. Walsh, and C. P. Richter, “Spatial extent of cochlear infrared neural stimulation determined by tone-on-light masking,” J. Biomed. Opt. 16, 118002:1-8 (2011).

9.
C. P. Richter, S. M. Rajguru, A. I. Matic, E. L. Moreno, A. J. Fishman, A. M. Robinson, E. Suh, and J. T. Walsh, “Spread of cochlear excitation during stimulation with pulsed infrared radiation: inferior colliculus measurements,” J. Neural Eng. 8, 056006 (2011). crossref(new window)

10.
A. D. Izzo, C. P. Richter, E. D. Jansen, and J. T. Walsh, “Laser stimulation of the auditory nerve,” Lasers Surg. Med. 38, 745-753 (2006). crossref(new window)

11.
A. D. Izzo, J. T. Walsh, E. D. Jansen, M. Bendett, J. Webb, H. Ralph, and C. P. Richter, “Optical parameter variability in laser nerve stimulation: a study of pulse duration, repetition rate, and wavelength,” IEEE Trans. Biomed. Eng. 54, 1108-1114 (2007). crossref(new window)

12.
C. P. Richter, R. Bayon, A. D. Izzo, M. Otting, E. Suh, S. Goyal, J. Hotaling, and J. T. Walsh, “Optical stimulation of auditory neurons: effects of acute and chronic deafening,” Hear. Res. 242, 42-51 (2008). crossref(new window)

13.
A. D. Izzo, J. T. Walsh, H. Ralph, J. Webb, M. Bendett, J. Wells, and C. P. Richter, “Laser stimulation of auditory neurons: effect of shorter pulse duration and penetration depth,” Biophys. J. 94, 3159-3166 (2008). crossref(new window)

14.
G. I. Wenzel, S. Balster, H. H. Lim, K. Zhang, U. Reich, and H. Lubatschowski, “Stimulation of the cochlea using green laser light,” Proc. SPIE 7161, 71611Z (2009).

15.
A. Fridberger and T. Ren, “Local mechanical stimulation of the hearing organ by laser irradiation,” NeuroReport 17, 33-37 (2006). crossref(new window)

16.
N. Xia, X. Y. Wu, X. Wang, Z. X. Mou, M. Q. Wang, X. Gu, X. L. Zheng, and W. S. Hou, “Pulsed 808-nm infrared laser stimulation of the auditory nerve in guinea pig cochlea,” Laser Med. Sci. 29, 343-349 (2014). crossref(new window)

17.
J. Wells, C. Kao, K. Mariappan, J. Albea, E. D. Jansen, P. Konrad, and A. Mahadevan-Jansen, “Optical stimulation of neural tissue in vivo,” Opt. Lett. 30, 504-506 (2005). crossref(new window)

18.
J. L. Boulnois and A. Morfino, “Photo-biomolecular effects of laser radiation,” Minerva Med. 74, 1669-1673 (1983).

19.
S. M. Rajguru, A. I. Matic, A. M. Robinson, A. J. Fishman, L. E. Moreno, A. Bradley, I. Vujanovic, J. Breen, J. D. Wells, M. Bendett, and C. P. Richter, “Optical cochlear implants: evaluation of surgical approach and laser parameters in cats,” Hear. Res. 269, 102-111 (2010). crossref(new window)

20.
S. Thomsen, “Pathologic analysis of photothermal and photomechanical effects of laser-tissue interactions,” Photochem. Photobiol. 53, 825-835 (1991). crossref(new window)

21.
A. J. Welch and M. J. C. Van Gemert, Optical-Thermal Response of Laser-Irradiated Tissue (Springer Press, Berlin, Germany, 2011).

22.
J. Wells, C. Kao, P. Konrad, T. Milner, J. Kim, A. Mahadevan-Jansen, and E. D. Jansen, “Biophysical mechanisms of transient optical stimulation of peripheral nerve,” Biophys. J. 93, 2567-2580 (2007). crossref(new window)