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Preparation and Characterization of Biodegradable Hydrogels for Tissue Expander Application
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  • Journal title : Polymer Korea
  • Volume 34, Issue 3,  2010, pp.253-260
  • Publisher : The Polymer Society of Korea
  • DOI :
 Title & Authors
Preparation and Characterization of Biodegradable Hydrogels for Tissue Expander Application
Yuk, Kun-Young; Kim, Ye-Tae; Im, Su-Jin; Garner, John; Fu, Yourong; Park, Ki-Nam; Park, Jeong-Sook; Huh, Kang-Moo;
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 Abstract
In this study, we prepared and evaluated a series of biocompatible and biodegradable block copolymer hydrogels with a delayed swelling property for tissue expander application. The hydrogels were synthesized via a radical crosslinking reaction of poly(ethylene glycol) (PEG) diacrylate and poly(D,L-lactide-co-glycolide)-poly(ethylene glycol)-poly(D,L-lactide-co-glycolide)(PLGA-PEG-PLGA) triblock copolymer diacrylate as a swelling/degradation controller (SDC). For the synthesis of various SDCs that can lead to different degradation and swelling properties, various PLGA-PEG-PLGA triblock copolymers with different LA/GA ratios and different PLGA block lengths were synthesized and modified to have terminal acrylate groups. The resultant hydrogels were flexible and elastic even in the dry state. The in vitro degradation tests showed that the delayed swelling properties of the hydrogels could be modulated by varying the chemical composition of the biodegradable crosslinker (SDC) and the block ratio of SDC/PEG. The histopathologic observation after implantation of hydrogels in mice was performed and evaluated by macrography and microscopy. Any significant inflammation or necrosis was not observed in the implanted tissues. Due to their biocompatibility, elasticity, sufficient swelling pressure, delayed swelling and controllable degradability, the hydrogels could be useful for tissue expansion and other biomedical applications.
 Keywords
biodegradable hydrogel;PEG;PLGA;tissue expander;delayed swelling;
 Language
Korean
 Cited by
1.
푸코이단을 함유한 Clay/아크릴아미드 하이드로젤,황선애;이종휘;

폴리머, 2011. vol.35. 4, pp.332-336
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