JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Bioequivalence for 2 X 2 Crossover Experiment with Missing Observations
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Bioequivalence for 2 X 2 Crossover Experiment with Missing Observations
Park, Sang-Gue; Choi, Young-Wook; Lim, Nam-Kyoo; Shin, Hyun-Chul;
  PDF(new window)
 Abstract
Statistical models and their inferences in a bioequivalence trial are considered and studied when the missing observations occurred in crossover experiment. Patel(1985) suggested the approximate test procedures for carryover effect and drug effect in crossover design. Bootstrap methods are proposed to implement Patel's test to the bioequivalence trial. Patel's work and its bootstrap methods are discussed with the current KFDA rule through the simulation studies and the recommendation is made.
 Keywords
bioequivalence;incomplete 22 crossover design;maximum likelihood estimators;bootstrap confidence intervals;
 Language
Korean
 Cited by
1.
2 × 2 교차설계에 의한 생물학적동등성시험에서 결측치가 있을 때의 통계적 해석 방법,박상규;이재영;최성업;윤미경;이재휘;최영욱;

Journal of Pharmaceutical Investigation, 2004. vol.34. 5, pp.379-383 crossref(new window)
 References
1.
Biometrical Journal, 1994. vol.36. pp.453-464 crossref(new window)

2.
Statistical Science, 1996. vol.11. pp.283-302 crossref(new window)

3.
Journal of Statistical Computation and Simulation, 2001. vol.68. pp.243-280 crossref(new window)

4.
Drug Information Journal, 1990. vol.24. pp.753-762

5.
Design and Anlaysis of Bioavailability and Bioequivalence Studies, 2000.

6.
Annals of Statistics, 1979. vol.7. pp.1-26 crossref(new window)

7.
Journal of the American Statistical Association, 1994. vol.89. pp.463-479 crossref(new window)

8.
An Introduction to the Bootstrap, 1993.

9.
Biometrics, 1965. vol.21. pp.467-480 crossref(new window)

10.
Biometrics, 1974. vol.30. pp.309-317 crossref(new window)

11.
Biometrika, 1973. vol.60. pp.101-105 crossref(new window)

12.
Biometrika, 1985. vol.72. pp.411-418 crossref(new window)

13.
Journal of Pharmacokinetics and Biopharmaceutics, 1987. vol.15. pp.657-680 crossref(new window)

14.
Statistics in Medicine, 2000. vol.19. pp.2741-2754 crossref(new window)

15.
Journal of the American Statistical Association, 1996. vol.91. pp.1278-1288 crossref(new window)

16.
Biometrics, 1976. vol.32. pp.741-744 crossref(new window)