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Nonparametric Procedure for Identifying the Minimum Effective Dose with Ordinal Response Data
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 Title & Authors
Nonparametric Procedure for Identifying the Minimum Effective Dose with Ordinal Response Data
Kang, Jongsook; Kim, Dongjae;
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 Abstract
The primary interest of drug development studies is identifying the lowest dose level producing a desirable effect over that of the zero-dose control, which is referred as the minimum effective dose (MED). In this paper, we suggest a nonparametric procedure for identifying the MED with binary or ordered categorical response data. Proposed test and Williams` test are compared by Monte Carlo simulation study and discussed.
 Keywords
Binary response;Minimum effective dose (MED);Nonparametric test;Monte Carlo study;Ordinal response;
 Language
English
 Cited by
 References
1.
Chen, Y. I. (1999). Nonparametric procedures for comparing umbrella pattern treatmenteffects with a control in a one-way layout, Biometrics, vol. 55, 1236-1240 crossref(new window)

2.
Chuang-stein, C. and Agresti, A. (1997). Tutorial in Biostatistics : A review of tests fordetecting a monotone dose-response relationship with ordinal response data.Statistics in medicine, vol. 16, 2599-2618 crossref(new window)

3.
Randles, R. H. and Wolfe, D. A. (1979). Introduction to the Theory of Nonparametric Statistics. New York : John Wiley

4.
Ruberg, S. J. (1989). Contrasts for identifying the minimum effective dose, Journal of the American Statistical Association, vol. 84, 816-822 crossref(new window)

5.
Shirley, E. A. (1977). Non-parametric equivalent of Williams' test for contrastingincreasing dose levels of a treatment, Biometrics, vol. 33, 386-389 crossref(new window)

6.
Tamhane, A. C., Hochberg Y., Dunnett, C. W. (1996). Multiple test procedures for dosefinding, Biometrics, Vol. 52, 21-37 crossref(new window)

7.
Terpstra, T. J. (1952). The asymptotic normality and consistency of Kendall's test againsttrend when ties are present in one ranking, Indagationes Mathematica, vol. 14,327-333

8.
Williams, D. A. (1971). A test for differences between treatment means when several doselevels are compared with a zero dose control, Biometrics, vol. 27, 103-117 crossref(new window)

9.
Williams, D. A. (1972). The compahson of several dose levels with a zero dose control,Biometrics, vol. 28, 519-531 crossref(new window)

10.
Williams, D. A. (1986). A note on Shirley's nonparametric test for comparing several doselevels with a zero-dose control, Biometrics, vol. 42, 183-186 crossref(new window)

11.
Williams, D. A. (1988). Tests for differences between several small proportions, AppIiedStatistics, vol. 37, 421-434