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Applications of Geostatistics to the Quantitative Analysis of Genetic Instability in Carcinogenesis
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 Title & Authors
Applications of Geostatistics to the Quantitative Analysis of Genetic Instability in Carcinogenesis
Kim Hyoung-Moon;
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It has long been recognized that cancer is a genetic disease. To find this measures of genetic instability, stain cells with chromosome specific probes using chromosome in-situ hybridization technique is adopted. Even though in-situ hybridization technique is powerful, truncation of nuclei often results in under-representation of chromosome copies in slides due to the sectioning of tissue blocks. Because of this problem we suggest three different methods to analyze the cervical cancer data set. We observe that genetic instability is an increasing function of histology and our suggested model is the best in detecting genetic instability of tumorigenesis processes.
Tumorigenesis;Geostatistics;Smoothing;Random-coefficient model;
 Cited by
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