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Detecting an Outlier in 2X2 Bioequivalence Trial
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 Title & Authors
Detecting an Outlier in 2X2 Bioequivalence Trial
Jeong, Gyu-Jin; Park, Sang-Gue; Woo, Hwa-Hyoung;
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Outlying or extreme observations are defined to be subject data for which one or more bioavailability measures are discordant with corresponding data for that subject and/or for the rest of the subjects in a study. The presence of outlying observations can have very serious consequences on the conclusions resulting from a bioequivalence study. Two statistical methods are proposed by generalizing the current well known methods and an illustrated example is presented with discussion.
crossover design;bioequivalence;estimates distance;likelihood distance;outlier;
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