Maximum Tolerated Dose Estimate by Curve Fitting in Phase I Clinical Trial Heo, Eun-Ha; Kim, Dong-Jae;
The purpose of a Phase I clinical trial is to estimate the maximum tolerated dose, MTD, of a new drug. In this paper, the MTD estimation method is suggested by curve fitting the dose-toxicity data to an S-shaped curve. The suggested MTD estimation method is compared with established MTD estimation procedures using a Monte Carlo simulation study.
Phase I clinical trial;Maximum tolerated dose(MTD);dose-toxicity curve;
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