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Nonparametric Tests for 2×2 Cross-Over Design
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 Title & Authors
Nonparametric Tests for 2×2 Cross-Over Design
Gee, Kyuhoon; Kim, Dongjae;
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A Cross-over design is widely used in clinical trials for comparison studies of two kinds of drugs or medical treatments. This design has many statistical methods such as Hills-Armitage's (1979) method or Koch's (1972) method. In this paper, we propose a nonparametric test for Cross-over design based on a two-sample test suggested by Baumgartner et al. (1998). In addition, a Monte Carlo simulation study is adapted to compare the power of the proposed methods with those of previous methods.
Cross-over design;two-sample tests;nonparametric;comparison of power;
 Cited by
Baumgartner, W., Weiss, P. and Schindler, H. (1998). A nonparametric test for the general two-sample problem, Biometrics, 54, 1129-1135. crossref(new window)

Grizzle, J. E. (1965). The two-period change over design and its use in clinical trials, Biometrics, 21, 467-480. crossref(new window)

Hills, A. V. and Armitage, P. (1979). The two-period cross-over clinical trial, British Journal of Clinical Pharmacology, 8, 7-20. crossref(new window)

Kim, D. (1999). Distribution-free tests for cross-over design data, The Korean Communications in Statistics, 6, 151-157.

Kim, D., Lee, S. C. andWang,W. (2011). The asymptotic behavior of linear placements statistics, Statistics and Probability Letters, 81, 326-336. crossref(new window)

Koch, G. G. (1972). The use of none-parametric methods in the statistical analysis of the two-period change over design, Biometrics, 28, 577-584. crossref(new window)

Park, Y. K. and Song, H. H. (1998). Analysis of Repeated Measures and Cross-Over Design, Freeacademy, Korea.