Nonparametric Tests for 2×2 Cross-Over Design Gee, Kyuhoon; Kim, Dongjae;
A Cross-over design is widely used in clinical trials for comparison studies of two kinds of drugs or medical treatments. This design has many statistical methods such as Hills-Armitage's (1979) method or Koch's (1972) method. In this paper, we propose a nonparametric test for Cross-over design based on a two-sample test suggested by Baumgartner et al. (1998). In addition, a Monte Carlo simulation study is adapted to compare the power of the proposed methods with those of previous methods.
Cross-over design;two-sample tests;nonparametric;comparison of power;
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