Maximum Tolerated Dose Estimation Applied Biased Coin Design in a Phase I Clinical Trial Kim, Yu Rim; Kim, Dongjae;
Phase I trials determine the maximum tolerated dose(MTD) and the recommended dose(RD) for subsequent Phase II trials. In this paper, a MTD estimation method applied to a biased coin design is proposed for Phase I Clinical Trials. The suggested MTD estimation method is compared to the SM3 method and the NM method (Lee and Kim, 2012) using a Monte Carlo simulation study.
Phase I clinical trial;maximum tolerated dose;recommended dose;biased coin design;
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