JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Comparison of Methods for Linkage Analysis of Affected Sibship Data
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Comparison of Methods for Linkage Analysis of Affected Sibship Data
Go, Min-Jin; Lim, Kil-Seob; Lee, Hak-Bae; Song, Ki-Jun;
  PDF(new window)
 Abstract
For complex diseases such as diabetes, hypertension, it is believed that model-free methods might work better because they do not require a precise knowledge of the mode of inheritance controlling the disease trait. This is done by estimating the sharing probabilities that a pair shares zero, one, or two alleles identical by descent(IBD) and has some specific branches of test procedure, i.e., the mean test, the proportion test, and the minmax test. Among them, the minmax test is known to be more robust than others regardless of genetic mode of inheritance in current use. In this study, we compared the power of the methods which are based on minmax test and considering weighting schemes for sib-pairs to analyze sibship data. In simulation result, we found that the method based on Suarez' was more powerful than any others without respect to marker allele frequency, genetic mode of inheritance, sibship size. Also, The power of both Suarez- and Hodge-based methods was higher when marker allele frequency and sibship size were higher, and this result was remarkable in dominant mode of inheritance especially.
 Keywords
Linkage analysis;affected sibship data;weighted method;power;
 Language
Korean
 Cited by
 References
1.
질병관리본부 만성병조사팀 (2003). 우리나라 고혈압 유병율 및 관리현황, 국민건강영양조사 3기 검진조사보고서

2.
Blackwelder, W. C. and Elston, R. C. (1985). A comparison of sib-pair linkage tests for disease susceptibility loci, Genetic Epidemiology, 2, 85-97 crossref(new window)

3.
Collins, A. and Morton, N. E. (1995). Nonparametric tests for linkage with dependent sib pairs, Human Heredity, 45, 311-318 crossref(new window)

4.
Haseman, J. K. and Elston, R. C. (1972). The investigation of linkage between a quantitative trait and a marker locus, Behavior Genetics, 2, 3-19 crossref(new window)

5.
Hodge, S. E. (1984). The information contained in multiple sibling pairs, Genetic Epidemiology, 1, 109-122 crossref(new window)

6.
Hodge, S. E. and Suarez, B. K. (1979). A simple method to detect linkage for rare recessive disease: An application to juvenile diabetes, Clinical Genetics, 15, 126-136 crossref(new window)

7.
Holmans, P. (1998). Affected sib-pair methods for detecting linkage to Dichotomous traits: Review of the methodology, Human Biology, 70, 1025-1040

8.
Knapp, M., Seuchter, S. A. and Baur, M. P. (1994a). Two-locus disease models with two marker loci: The power of affected-sib-pair tests, American Journal of Human Genetics, 55, 1030-1041

9.
Knapp, M., Seuchter, S. A. and Baur, M. P. (1994b). Linkage analysis in nuclear families. 1: Optimality criteria for affected sib-pair tests, Human Heredity, 44, 37-43 crossref(new window)

10.
Knapp, M. and Strauch, K. (2004). Affected-sib-pair test for linkage based on constraints for identicalby-Descent distributions corresponding to disease models with imprinting, Genetic Epidemiology, 26, 273-285 crossref(new window)

11.
Kruglyak, L., Daly, M. J., Reeve-Daly, M. P. and Lander, E. S. (1996). Parametric and nonparametric linkage analysis: A unified multipoint approach, American Journal of Human Genetics, 58, 1347-1363

12.
Olson, J. M., Goddard, K. A. and Dudek, D. M. (2002). A second locus for very-late-onset Alzheimer disease:a genome scan reveals linkage to 20p and epistasis between 20p and the amyloid precursor protein region, American Journal of Human Genetics, 71, 154-161 crossref(new window)

13.
Olson, J. M., Witte, J. S. and Elston, R. C. (1999). Tutorial in biostatistics genetic mapping of complex traits, Statistics in Medicine, 18, 2961-2981 crossref(new window)

14.
Ott, J. (1999). Analysis of Human Genetic Linkage, 3rd edition, The johns Hopkins University Press, Baltimore

15.
Payami, H., Thomson, G. and Louis, E. J. (1984). The affected sib method. III. Selection and recombination, American Journal of Human Genetics, 36, 352-362

16.
Penrose, L. S. (1935). The detection of autosomal linkage in data which consist of pairs of brothers and sisters of unspecified parentage, Annals of Engenics, 6, 133-138 crossref(new window)

17.
Sham, P. C., Zhao, J. H. and Curtis, D. (1997). Optimal weighting scheme for affected sib-pair analysis of sibship data, Annals of Human Genetics, 61, 61-69 crossref(new window)

18.
Suarez, B. K., Rice, J. and Reich, T. (1978). The generalized sib pair lBD distribution: Its use in the detection of linkage, Annals of Human Genetics, 42, 87-94 crossref(new window)

19.
Thomson, G. (1986). Determining the mode of inheritance of RFLP-associated diseases using the affected sib-pair method, American Journal of Human Genetics, 39, 207-221

20.
Whittemore, A. S. and Tu, I. P. (1998). Simple, Robust linkage tests for affected sibs, American Journal of Human Genetics, 62, 1228-1242 crossref(new window)