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Comparison of Methods for Linkage Analysis of Affected Sibship Data
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 Title & Authors
Comparison of Methods for Linkage Analysis of Affected Sibship Data
Go, Min-Jin; Lim, Kil-Seob; Lee, Hak-Bae; Song, Ki-Jun;
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For complex diseases such as diabetes, hypertension, it is believed that model-free methods might work better because they do not require a precise knowledge of the mode of inheritance controlling the disease trait. This is done by estimating the sharing probabilities that a pair shares zero, one, or two alleles identical by descent(IBD) and has some specific branches of test procedure, i.e., the mean test, the proportion test, and the minmax test. Among them, the minmax test is known to be more robust than others regardless of genetic mode of inheritance in current use. In this study, we compared the power of the methods which are based on minmax test and considering weighting schemes for sib-pairs to analyze sibship data. In simulation result, we found that the method based on Suarez` was more powerful than any others without respect to marker allele frequency, genetic mode of inheritance, sibship size. Also, The power of both Suarez- and Hodge-based methods was higher when marker allele frequency and sibship size were higher, and this result was remarkable in dominant mode of inheritance especially.
Linkage analysis;affected sibship data;weighted method;power;
 Cited by
질병관리본부 만성병조사팀 (2003). 우리나라 고혈압 유병율 및 관리현황, 국민건강영양조사 3기 검진조사보고서

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