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Comparison of Trend Tests for Genetic Association with Sibship Data
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 Title & Authors
Comparison of Trend Tests for Genetic Association with Sibship Data
Oh, Young-Sin; Kim, Han-Sang; Son, Hae-Hiang;
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 Abstract
Extensively used case-control designs in medical studies can also be powerful and efficient for family association studies as long as an analysis method is developed for the evaluation of association between candidate genes and disease. Traditional Cochran-Armitage trend test is devised for independent subjects data, and to apply this trend test to the biologically related siblings one has to take into account the covariance among related family members in order to maintain the correct type I error rate. We propose a more powerful trend test by introducing weights that reflect the number of affected siblings in families for the evaluation of the association of genetic markers related to the disease. An application of our method to a sample family data, in addition to a small-scale simulation, is presented to compare the weighted and unweighted trend tests.
 Keywords
Cochran-Armitage trend test;case-control designs;genetic association;sibship data;
 Language
Korean
 Cited by
1.
이산형 형질에 대한 가족자료 연관성 검정법 FBAT와 형제 전달 불균형 연관성 검정법 S-TDT의 비교,김한상;오영신;송혜향;

응용통계연구, 2010. vol.23. 6, pp.1103-1113 crossref(new window)
1.
Comparison of the Family Based Association Test and Sib Transmission Disequilibrium Test for Dichotomous Trait, Korean Journal of Applied Statistics, 2010, 23, 6, 1103  crossref(new windwow)
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