Comparison of Trend Tests for Genetic Association with Sibship Data Oh, Young-Sin; Kim, Han-Sang; Son, Hae-Hiang;
Extensively used case-control designs in medical studies can also be powerful and efficient for family association studies as long as an analysis method is developed for the evaluation of association between candidate genes and disease. Traditional Cochran-Armitage trend test is devised for independent subjects data, and to apply this trend test to the biologically related siblings one has to take into account the covariance among related family members in order to maintain the correct type I error rate. We propose a more powerful trend test by introducing weights that reflect the number of affected siblings in families for the evaluation of the association of genetic markers related to the disease. An application of our method to a sample family data, in addition to a small-scale simulation, is presented to compare the weighted and unweighted trend tests.
Comparison of the Family Based Association Test and Sib Transmission Disequilibrium Test for Dichotomous Trait, Korean Journal of Applied Statistics, 2010, 23, 6, 1103
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