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Comparison of the Family Based Association Test and Sib Transmission Disequilibrium Test for Dichotomous Trait
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 Title & Authors
Comparison of the Family Based Association Test and Sib Transmission Disequilibrium Test for Dichotomous Trait
Kim, Han-Sang; Oh, Young-Sin; Song, Hae-Hiang;
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An extensively used approach for family based association test(FBAT) is compared with the sib transmission/disequilibrium test(S-TDT), and in particular the adjusted S-TDT, in which the covariance among related siblings is taken into consideration, can provide a more sensitive test statistic for association. A simulation study comparing the three test statistics demonstrates that the type I error rates of all three tests are larger than the prespecified significance level and the power of the FBAT is lower than those of the other two tests. More detailed studies are required in order to assess the influence of the assumed conditions in FBAT on the efficiency of the test.
Genetic association test;family data;FBAT;S-TDT;
 Cited by
오영신, 김한상, 송혜향 (2010). 형제자료에 근거한 유전연관성 추세 검정법의 비교, <응용통계연구>, 23, 845– 855. crossref(new window)

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