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Model Validation Methods of Population Pharmacokinetic Models
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 Title & Authors
Model Validation Methods of Population Pharmacokinetic Models
Lee, Eun-Kyung;
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The result of the analysis of a population pharmacokinetic model can directly influence the decision of the dose level applied to the targeted patients. Therefore the validation procedure of the final model is very important in this area. This paper reviews the validation methods of population pharmacokinetic models from a statistical viewpoint. In addition, the whole procedure of the analysis of population pharmacokinetics, from the base model to the final model (that includes various validation procedures for the final model) is tested with real clinical data.
Population pharmacokinetics;mixed effect model;nonlinear function;model validation;
 Cited by
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