Detecting Genetic Association and Gene-Gene Interaction using Network Analysis in Case-Control Study Jin, Seo-Hoon; Lee, Min-Hee; Lee, Hyo-Jung; Park, Mi-Ra;
Various methods of analysis have been proposed to understand the gene-disease relation and gene-gene interaction effect for a disease through comparison of genotype in case-control study. In this study, we proposed the method to detect a genetic association and gene-gene interaction through the use of a network graph and centrality measures that are used in social network analysis. The applicability of the proposed method was studied through an analysis of real genetic data.
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