Advanced SearchSearch Tips
A Comparison between Effects of Anorexia Induced by Consecutive Low-Dose Cisplatin and High-Dose Cisplatin on Hindlimb Muscles of Rats
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
A Comparison between Effects of Anorexia Induced by Consecutive Low-Dose Cisplatin and High-Dose Cisplatin on Hindlimb Muscles of Rats
Kim, Jin-Il; Choe, Myoung-Ae;
  PDF(new window)
Purpose: The purpose of this study was to compare the effects of anorexia induced by consecutive low-dose and high-dose of cisplatin (CDDP) on the hindlimb muscles of rats. Methods: Male Sprague-Dawley rats were assigned to three groups: Control group (C) received a saline (the same dose and duration as the low CDDP group), the high-dose cisplatin (High CDDP) group received a single 5 mg/kg dose of cisplatin, the consecutive low-dose cisplatin (Low CDDP) group had 1 mg/kg of cisplatin administered for five consecutive days. On the 8th day the soleus and gastrocnemius muscles were dissected. Body weight, food intake, activity, muscle weight, Type I, II fiber cross-sectional area (CSA) of the dissected muscles were measured. Results: Body weight, food intake, muscle weight and Type I, II fiber CSA of the High CDDP and Low CDDP groups were significantly less than the C group. The High CDDP group showed significant decreases, compared to the Low CDDP group, in body weight, food intake, activity score, muscle weight and Type I, II fiber CSA. Conclusion: Hindlimb muscle atrophy occurs due to anorexia induced by both consecutive low-dose and high-dose cisplatin. The muscle atrophy induced by consecutive low-dose cisplatin is less apparent than high-dose cisplatin.
Chemotherapy;Cisplatin;Muscular atrophy;Rat;
 Cited by
항산화제가 시스플라틴에 의해 유발된 쥐의 뒷다리근 위축 경감에 미치는 영향,김진일;최명애;

대한간호학회지, 2014. vol.44. 4, pp.371-380 crossref(new window)
Effects of Antioxidant on Reduction of Hindlimb Muscle Atrophy Induced by Cisplatin in Rats, Journal of Korean Academy of Nursing, 2014, 44, 4, 371  crossref(new windwow)
An, G. J., & Choe, M. A. (2002). Effect of DHEA on Type I and II muscles in a focal cerebral ischemia model rat. Journal of Korean Biological Nursing Science, 4(2), 19-40.

Araki, H., Fukushima, M., Kamiyama, Y., & Shirasaka, T. (2000). Effect of consecutive lower-dose cisplatin in enhancement of 5-fluorouracil cytotoxicity in experimental tumor cells in vivo. Cancer Letters, 160, 185-191. crossref(new window)

Authier, N., Gillet, J. P., Fialip, J., Eschalier, A., & Coudore, F. (2003). An animal model of nociceptive peripheral neuropathy following repeated cisplatin injections. Experimental Neurology, 182(1), 12-20. crossref(new window)

Bocci, G., Francia, G., Man, S., Lawler, J., Kerbel, R. S. (2003). Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proceedings of the National Academy of Sciences of the United States of America, 100, 12917-12922. crossref(new window)

Browder, T., Butterfield, C. E., Kräling, B. M., Shi, B., Marshall, B., O'Reilly, M. S., et al. (2000). Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Research, 60, 1878-1886.

Cabezos, P. A., Vera, G., Martin-Fontelles, M. I., Fernandez-Pujol, R., & Abalo, R. (2010). Cisplatin-induced gastrointestinal dysmotility is aggravated after chronic administration in the rat. Comparison with pica. Neurogastroenterology and Motility, 22, 797-805. crossref(new window)

Castaneda, C. (2002). Muscle wasting and protein metabolism. Journal of Animal Science, 80(Suppl 2), E98-105.

Choe, M. A., An, G. J., Lee, Y. K., Im, J. H., Choi-Kwon, S., & Heitkemper, M. (2004). Effect of inactivity and undernutrition after acute ischemic stroke in a rat hindlimb muscle model. Nursing Research, 53, 283-292. crossref(new window)

Choe, M. A., Kim, K. H., An, G. J., Lee, K. S., & Choi, J. (2008). Hindlimb muscle atrophy of rat induced by neuropathic pain. Journal of Korean Biological Nursing Science, 10(1), 88-95.

Choi, Y. H., Li, C., Hartzell, D. L., Little, D. E., Della-Fera, M. A., & Baile, C. A. (2008). ICV leptin effects on spontaneous physical activity and feeding behavior in rats. Behavioural Brain Research, 188(1), 100-108. crossref(new window)

Damrauer, J., Stadler, M., Acharyya, S., Baldwin, A. S., Couch, M. E. Jr., & Guttridge, D. (2008). Chemotherapy-induced muscle wasting: association with NF-kB and cancer cachexia. Basic and Applied Myology, 18, 139-148.

Decatris, M. P., Sundar, S., & O'Byrne, K. J. (2004). Platinum-based chemotherapy in metastatic breast cancer: current status. Cancer Treatment Reviews, 30(1), 53-81. crossref(new window)

Eisenberg, P., Figueroa-Vadillo, J., Zamora, R., Charu, V., Hajdenberg, J., Cartmell, A., et al. (2003). Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist: results of a phase III, single-dose trial versus dolasetron. Cancer, 98, 2473-2482. crossref(new window)

Gelfi, C., Vigano, A., De Palma, S., Ripamonti, M., Begum, S., Cerretelli, P., et al. (2006). 2-D protein maps of rat gastrocnemius and soleus muscles: a tool for muscle plasticity assessment. Proteomics, 6(1), 321-340. crossref(new window)

Glendenning, J. L., Barbachano, Y., Norman, A. R., Dearnaley, D. P., Horwich, A., & Huddart, R. A. (2010). Long-term neurologic and peripheral vascular toxicity after chemotherapy treatment of testicular cancer. Cancer, 116, 2322-2331.

Hanigan, M. H., & Devarajan, P. (2003). Cisplatin nephrotoxicity: Molecular mechanisms. Cancer Therapy, 1, 47-61.

Ihbe-Heffinger, A., Ehlken, B., Bernard, R., Berger, K., Peschel, C., Eichler, H. G., et al. (2004). The impact of delayed chemotherapy-induced nausea and vomiting on patients, health resource utilization and costs in German cancer centers. Annals of Oncology, 15, 526-536. crossref(new window)

Jagoe, R. T., Lecker, S. H., Gomes, M., & Goldberg, A. L. (2002). Patterns of gene expression in atrophying skeletal muscles: response to food deprivation. FASEB Journal, 16, 1697-1712. crossref(new window)

Jordan, K., Kasper, C., & Schmoll, H. J. (2005). Chemotherapy-induced nausea and vomiting: current and new standards in the antiemetic prophylaxis and treatment. European Journal of Cancer, 41(2), 199-205. crossref(new window)

Karakas, A., Serin, E., & Güdüz, B. (2006). Food restriction affects locomotor activity in mongolian gerbils (Meriones unguiculatus). Turkish Journal of Biology, 30(1), 23-28.

Kerbel, R. S., Kamen, B. A. (2004). The anti-angiogenic basis of metronomic chemotherapy. Nature Reviews. Cancer 4, 423-436.

Kim, J. I., & Choe, M. A. (2009). Effects of unilateral sciatic nerve injury on unaffected hindlimb muscles of rats. Journal of Korean Academy of Nursing, 39, 393-400. crossref(new window)

Kim, J. Y. (2005). Effects of short-term undernutrition on type I, II muscles in rat. Unpublished master's dissertation, Seoul National University, Seoul.

Midtgaard, J., Baadsgaard, M. T., Møller, T., Rasmussen, B., Quist, M., Andersen, C., et al. (2009). Self-reported physical activity behaviour; exercise motivation and information among Danish adult cancer patients undergoing chemotherapy. European Journal of Oncology Nursing, 13(2), 116-121. crossref(new window)

Ohno, T., Kato, S., Wakatsuki, M., Noda, S. E., Murakami, C., Nakamura, M., et al. (2006). Incidence and temporal pattern of anorexia, diarrhea, weight loss, and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin: comparison with radiation therapy alone. Gynecologic Oncology, 103(1), 94-99. crossref(new window)

Park, S. T., Jang, J. W., Kim, G. D., Park, J. A., Hur, W., Woo, H. Y., et al. (2010). Beneficial effect of metronomic chemotherapy on tumor suppression and survival in a rat model of hepatocellular carcinoma with liver cirrhosis. Cancer Chemotherapy and Pharmacology, 65, 1029-1037. crossref(new window)

Shen, F. Z., Wang, J., Liang, J., Mu, K., Hou, J. Y., & Wang, Y. T. (2010). Low-dose metronomic chemotherapy with cisplatin: can it suppress angiogenesis in H22 hepatocarcinoma cells? International journal of experimental pathology, 91(1), 10-16. crossref(new window)

Yakabi, K., Sadakane, C., Noguchi, M., Ohno, S., Ro, S., Chinen, K., et al. (2010). Reduced ghrelin secretion in the hypothalamus of rats due to cisplatin-induced anorexia. Endocrinology, 151, 3773-3782. crossref(new window)

Yang, J. S. (2012). Effect of anorexia and neuropathic pain induced by cisplatin on hindlim muscles of rat. Unpublished master's dissertation, Seoul National University, Seoul.

Young, S. D., Whissell, M., Noble, J. C., Cano, P. O., Lopez, P. G., & Germond, C. J. (2006). Phase II clinical trial results involving treatment with low-dose daily oral cyclophosphamide, weekly vinblastine, and rofecoxib in patients with advanced solid tumors. Clinical Cancer Research, 12, 3092-3098. crossref(new window)