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3D QSAR Study on Pyrrolopyrimidines-Based Derivatives as LIM2 Kinase Inhibitors
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  • Journal title : Journal of the Chosun Natural Science
  • Volume 8, Issue 4,  2015, pp.285-292
  • Publisher : The Research Institute of Chosun Natural Science
  • DOI : 10.13160/ricns.2015.8.4.285
 Title & Authors
3D QSAR Study on Pyrrolopyrimidines-Based Derivatives as LIM2 Kinase Inhibitors
Balasubramanian, Pavithra K.; Balupuri, Anand; Cho, Seung Joo;
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LIM kinases belong to the serine/Threonine kinase family. The members of the LIM kinase (LIMK) family include LIMK 1 and 2 which are involved in the regulation of actin polymerisation and microtubule disassembly. LIMK1 was shown to be involved in cancer metastasis, while LIMK2 activation promotes cells cycle progression. Since LIMK2 plays a vital role in many disease conditions such as pulmonary hypertension, cancer and viral diseases, and till date there are not much selective inhibitors been reported, LIMK2 becomes an interesting therapeutic target among the kinases. 3D QSAR study was carried out on a series of pyrrolopyrimidines based derivatives as LIMK2 inhibitors. A reasonable CoMFA (
LIMK2;CoMFA;Pyrrolopyrimidines;LIM Kinase;Inhibitors;
 Cited by
3D QSAR Studies of Mps1 (TTK) Kinase Inhibitors Based on CoMFA,;;;

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