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Investigation of Enantiomer Separation Using Chiral Crown Ethers as Chiral Selectors
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  • Journal title : Journal of the Chosun Natural Science
  • Volume 9, Issue 1,  2016, pp.28-34
  • Publisher : The Research Institute of Chosun Natural Science
  • DOI : 10.13160/ricns.2016.9.1.28
 Title & Authors
Investigation of Enantiomer Separation Using Chiral Crown Ethers as Chiral Selectors
Lee, Wonjae;
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 Abstract
A number of chiral selectors have been developed and applied for enantiomer separation of a variety of chiral compounds. Among these chiral selectors are chiral crown ethers, a class of synthetic host polyether molecules that bind protonated chiral primary amines with high selectivity and affinity. In this paper, two important chiral crown ethers as chiral selectors of bis-(1,1`-binaphthyl)-22-crown-6 and (18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) are focused. They have been widely used to resolve the enantiomers of chiral compounds containing a primary amino moiety using chiral stationary phases (CSPs) or chiral selectors by high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and so on in chirotechnology. Also, it was described that the commercially available covalent type HPLC CSPs derived from (+)- and (-)-18-C-6-TA have been developed and successfully applied for the resolution of various primary amino compounds including amino acids.
 Keywords
Chiral Crown Ether;Chiral Selector;Chiral Stationary Phase;18-Crown-6-2,3,11,12-tetracarboxylic Acid;Capillary Electrophoresis;High-performance Liquid Chromatography;
 Language
English
 Cited by
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