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3D QSAR Studies of Mps1 (TTK) Kinase Inhibitors Based on CoMFA
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  • Journal title : Journal of the Chosun Natural Science
  • Volume 9, Issue 2,  2016, pp.113-120
  • Publisher : The Research Institute of Chosun Natural Science
  • DOI : 10.13160/ricns.2016.9.2.113
 Title & Authors
3D QSAR Studies of Mps1 (TTK) Kinase Inhibitors Based on CoMFA
Balasubramanian, Pavithra K.; Balupuri, Anand; Cho, Seung Joo;
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 Abstract
Monopolar spindle 1 (Mps1) is an attractive cancer target due to its high expression levels in a wide range of cancer cells. Mps1 is a dual specificity kinase. It plays an essential role in mitosis. The high expression od Mps1 was observed in various grades of breast cancers. In the current study, we have developed a CoMFA model of pyridazine derivatives as Mps1 kinase inhibitors. The developed CoMFA model ($q^2
 Keywords
CoMFA;Monopolar Spindle Kinase (Mps1);TTK Kinase;Pyridazine Derivatives;Kinase Inhibitors;
 Language
English
 Cited by
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