JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Monitoring for cephalosporins residues in raw meat in Seoul
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Korean Journal of Veterinary Service
  • Volume 38, Issue 4,  2015, pp.259-264
  • Publisher : The Korean Society of Veterinary Service
  • DOI : 10.7853/kjvs.2015.38.4.259
 Title & Authors
Monitoring for cephalosporins residues in raw meat in Seoul
Kim, Mi-Ran; Choi, Yoon-Hwa; Choi, Hoon; Kim, Doo-Hwan; Kim, Young-Seob; Lee, Ju-Hyung;
  PDF(new window)
 Abstract
We investigated the residues of 6 cephalosporins (cefquinome, cephalexin, cephalonium, cefazolin, ceftiofur, cefuroxime) using LC-MS/MS in raw meat in Seoul. This method involves extraction of the residue from the meat by distilled water and methanol followed by a manual of residue analysis published by the National Institute of Food and Drug Safety Evaluation. The recoveries ranged between 74.71~90.01% in beef, 73.37~101.40% in pork and 70.87~95.53% in chicken, respectively. The limits of detection were 0.0004~0.0563 mg/kg, and the limits of quantification were 0.001~0.169 mg/kg respectively. Residues of cephalosporins which exceeded maximum residue limits (MRL) were not exceed in any of the 287 samples. However, it is necessary to develop multi-method, which includes the active metabolites of ceftiofur.
 Keywords
Cephalosporins residues;Raw meat;LC-MS/MS;
 Language
Korean
 Cited by
 References
1.
농림수산검역검사본부. 2009. 수의과학기술개발연구사업 연구성과 활용집. pp. 243-432.

2.
농림수산검역검사본부. 2012. 2011년도 축산 항생제내성균 감시체계 구축 보고서.

3.
농림축산검역본부. 2013a. 2012년도 축산 항생제내성균 감시체계 구축 보고서.

4.
농림축산검역본부. 2013b. 동물용 의약품 안전사용 기준. 농림축산검역본부고시 제2013-28호.

5.
농림축산검역본부. 2014. 2013년도 국가 항생제 사용 및 내성모니터링 : 가축, 축.수산식품.

6.
농림축산검역본부. 2015. 2014년도 국내산 식육 잔류물질 검사결과 보고.

7.
식품의약품안전처. 2013. 식품공전. 식품의약품안전처고시 제2014-117호.

8.
식품의약품안전평가원. 2013. 축수산물 유해물질 분석법 편람. pp. 78-82.

9.
한국수의내과학교수협의회. 2013. 대동물내과학. 교육문화원, 서울.

10.
Australian Government department of agriculture, Animal product monitoring results tables 2013-14 Meat, Poultry Annual Results 2013-2014, Beef Annual Report 2013-2014 http://www.agriculture.gov.au/SiteCollectionDocuments/agriculture-food/nrs/2013-14-results/cattle.pdf, http://www.agriculture.gov.au/SiteCollectionDocuments/agriculturefood/nrs/2013-14-results/poultry.pdf

11.
Becker M. 2004. Residue analysis of 15 penicillins and cephalosporins in bovine muscle, kidney and milk by liquid chromatography-tandem mass spectrometry. Analytica Chimica Acta 520: 19-32. crossref(new window)

12.
Berendsen BJ, Stolker LA, Nielen MW. 2012. Assessment of liquid chromatography-tandem mass spectrometry approaches for the analysis of ceftiofur metabolites in poultry muscle. Food Addit Contam 29: 197-207. crossref(new window)

13.
Cho JK, Sung MS, Kim JH, Kim KS. 2011. Detection of CTX-M and TEM type extended-spectrum $\beta$-lactamase in Escherichia coli isolated from livestocks in Korea. Korean J Vet serv 34: 37-43. crossref(new window)

14.
Dancer SJ. 2001. The problem with cephalosporins. J Antimicrob Chemother 48: 463-478. crossref(new window)

15.
FDA. 2012. CODEX Guideline for validation of Chemical Methods for the FDA Foods Program. Appendix 2. pp. 25-26.

16.
FDA. 2015. Electronic Code of Federal Regulations, Food and drugs, Chapter I Subchapter E.

17.
Geis-Asteggiante L. Lehotay SJ, Lightfield AR, Dutko T, Ng C, Bluhm L. 2012. Ruggedness testing and validation of practical analytical method for > 100 veterinary drug residues in bovine muscle by ultrahigh performance liquid chromatography-tandem mass spectrometry. J chromatogr A 1258: 43-54. crossref(new window)

18.
Haas M, Gryaznor A. 2011. Amendment to sanitary norms establishes several new MRLs. USDA Foreign agricultural service Appendix 21. pp. 20-21

19.
Junza A, Amatya R, Perez-burgos R, Gokce G, Grzelak E, Barron D, Barbosa J. 2010. Residues of $\beta$-lactams and quinolones in tissues and milk samples. Confirmatory analysis by liquid chromatography-mass spectrometry. Annals of Chemistry 21: 109-122.

20.
Junza A, Amatya R, Barron D, Barbosa J. 2011. Comparative study of the LC-MS/MS and UPLC-MS/MS for the multi- residue analysis of quinolones, penicillins and cephalosporins in cow milk and validation according to the regulation 2002/657/EC. J Chromatogr B Analyt Technol Biomed Life Sci. 879: 2601-2610. crossref(new window)

21.
Perez-Burgos R, Grzelak EM, Gokce G, Saurina J, Barbosa J, Barron D. 2012. Quechers methodologies as an alternative to solid phase extraction(SPE) for the determination and characterization of residues of cephalosporins in beef muscle using LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 899: 57-65. crossref(new window)

22.
Phillip I. 2007. Withdrawal of growth-promoting antibiotics in Europe and its effects in relation to human health. Int J Antimicrob Agents 30: 466-468. crossref(new window)

23.
Samanadiu VF, Nisyriou SA, Papadoyannis IN. 2007. Development and validation of an HPLC method for the determination of penicillin antibiotics residues in bovine muscle according to the European Union Decision. J Sep Sci 30: 3193-3201. crossref(new window)

24.
Santos LLD, Moura RA, Aguilar-Ramires P, Castro APD, Lincopan N. 2013. Current status of extended-spectrum $\beta$-lactamase(ESBL)-producing Enterobacteriaceae in animals. Microbial pathogens and strategies for combating them:science, technology and education FORMATEX 2013: 1600-1607.

25.
The Codex Alimentarius Commission. 2014. Maximum residue limits(MRLs) and risk management recommendations (RMRs) for residues of veterinary drugs in foods. pp. 7.

26.
Wegener HC. 2003. Antibiotics in animal feed and their role in resistance development. Curr opin Microbiol 6: 439-445. crossref(new window)