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Antihyperglycemic α-Glucosidase Inhibitory Activity of Ethanol Extract from Neolentinus lepideus
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  • Journal title : The Korean Journal of Mycology
  • Volume 43, Issue 3,  2015, pp.174-179
  • Publisher : The Korean Society of Mycology
  • DOI : 10.4489/KJM.2015.43.3.174
 Title & Authors
Antihyperglycemic α-Glucosidase Inhibitory Activity of Ethanol Extract from Neolentinus lepideus
Shin, Ja-Won; Bae, Sang-Min; Han, Sang-Min; Lee, Yun-Hae; Kim, Jeong-Han; Ji, Jeong-Hyun; Lee, Jong-Soo;
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For development a new anti-diabetic compound from edible mushroom, antihyperglycemic -glucosidase inhibitory activities of Pleurotus ostreatus, Pleurotus cornucopiae, Pleurotus salmoneostramineus, Pleurotus eryngii and Neolentinus lepideus were investigated on its water and ethanol extracts. -Glucosidase inhibitory activity of Neolentinus lepideus fruiting body showed the highest at 86.3% in the 95% ethanol extracts and water extract from Pleurotus cornucopiae was also higher at 48.5% among water extracts. Therefore, Neolentinus lepideus which showed very high -glucosidase inhibitory activity was selected as a new anti-diabetic agent-containing mushroom and the -glucosidase inhibitor was maximally extracted when treated with 95% ethanol at for 48 hr. The ethanol extracts from Neolentinus lepideus fruiting body showed dosage-dependent hypoglycemic action after administration to 120 min in the SD-rat and streptozotocin-induced diabetic SD-rat.
Antihyperglycemic effect;-Glucosidase inhibitor;Neolentinus lepideus;
 Cited by
α-Glucosidase 저해물질을 함유한 노랑느타리버섯 (Pleurotus cornucopiae) 물추출물의 혈당상승 억제 효과,신자원;배상민;한상민;이윤혜;정윤경;지정현;이종수;

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