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The Preparation and Release Property of Alginate Microspheres Coated Gelatin-cinnamic Acid
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  • Journal title : Applied Chemistry for Engineering
  • Volume 24, Issue 5,  2013, pp.471-475
  • Publisher : The Korean Society of Industrial and Engineering Chemistry
  • DOI : 10.14478/ace.2013.24.5.471
 Title & Authors
The Preparation and Release Property of Alginate Microspheres Coated Gelatin-cinnamic Acid
Lee, Ju Hyup; Ma, Jin Yeul; Kim, Jin-Chul;
This study is about photosensitive microspheres prepared by coating alginate microspheres with gelatin-cinnamic acid conjugate. Firstly, alginate microspheres was prepared in water-in-oil (W/O) emulsion and then they were coated with gelatin- cinnamic acid conjugate. Herein, gelatin-cinnamic acid conjugate is obtained by the amidation between an amine group of gelatin and a carboxy group of cinnamic acid. Cinnamic acid is widely used as a photo-responsive material easy to dimerize and dedimeriz under UV irradiation at = 254 nm and = 365 nm, respectively. As shown in SEM-EDS, alginate was successfully coated with gelatin-ciannmic acid. By determining the absorbance of coated microspheres at 270nm, the amount of cinnamic acid per microspheres was 0.13/1. The SEM photos showed the size of coated microspheres is around . And the degrees of dimerization and dedimerization were calculated to be 49% and 23% respectively. Then the release of FITC-dextran from the coated micrspheres was studied and release the degree was 42%. As a result, the coated microspheres have potential to be used as a photo-responsive drug carrier to delivery drugs.
alginate microspheres;gelatin;Cinnamic acid;photo sensitivity;
 Cited by
J. M. Russell, S. H. Allan, A. P. Pauli, S. B. Lisa, and R. G. Wayne, Calcium-alginate beads for the oral delivery of transforming growth factor-${\beta}1$ (TGF-${\beta}1$) : stabilization of TGF-${\beta}1$ by the addition of polyacrylic acid within acid-treated beads, Journal of Controlled Release, 30, 3 (1994).

N. M. Velings and M. M. Mestdagh, Physico-chemical properties of alginate gel beads, Polymer Gels and Networks, 3, 311 (1995). crossref(new window)

S. M. Jay and W. M. Saltman, Controlled delivery of VEGF via modulation of alginate microparticle ionic crosslinking, Journal of Controlled Release, 134, 26 (2009). crossref(new window)

M. G. Neumann, C. C. Schmitt, and E. T, Lamazaki, A fluorescence study of the interactions between sodium alginate and surfactants, Carbohydrate Research, 338, 1109 (2003). crossref(new window)

M. George and T. E. Abraham, Polyionic hydrocolloids for the intestinal delivery of protein drugs: Alginate and chitosan - a review, Journal of Controlled Release, 114, 1 (2006). crossref(new window)

M. K. Kang, J. Dai, and J.-C. Kim, Ethylcellulosemicroparticles containing chitosan and gelatin: pH-dependent release caused by complex coacervation, Journal of Industrial and Engineering Chemistary, 18, 355 (2012).

A. Bigia, G. Cojazzib, S. Panzavoltaa, K. Rubinia, and N. Roveria, Mechanical and thermal properties of gelatin films at different degrees of glutaraldehyde crosslinking, Biomaterials, 22, 763 (2001). crossref(new window)

K. Ulubayrama, A. N. Cakarb, P. Korkuguzb, C. Ertanc, N. Hagirci, and N. Hagirci, EGF containing gelatin-based wound dressings, Biomaterials, 22, 1345 (2001). crossref(new window)

U. G. Spizzirri, F. Iemma, F. Puoci, G. Cirillo, M. Curcio, O. I. Parigi, and N. Picci, Synthesis of Antioxidant Polymers by Grafting of Gallic Acid and Catechin on Gelatin, Biomacromolecules, 10, 1923 (2009). crossref(new window)

H. C. Liang, W. H. Chang, K. J. Lin, and H. W. Sung, Genipincrosslinked gelatin microspheres as a drug carrier for intramuscular administration: In vitro and in vivo studies, Journal of Biomedical Materials Research Part A, 65, 271 (2003).

M. Gudmundsson and H. Hafsteinsson, Gelatin from cod skins as affected by chemical treatments, Journal of Food Science, 62, 37 (1997). crossref(new window)

H. L. Bruno, Investigation of viscosity and gelation properties of different mammalian and fish gelatins, Food Hydrocolloids, 5, 353 (1991). crossref(new window)

Y. Qiu and K. Park, Environment-sensitive hydrogels for drug delivery, Advanced Drug Delivery Reviews, 64, 49 (2012). crossref(new window)

E. Y. Mok, H. J. Cha, and J. C. Kim, Preparation and Characterization of Complex Composed of ${\beta}$-Cyclodextrin Polymer/Cinnamic Acid, Appl. Chem. Eng, 23, 462 (2012).

J. H. Ko, H. Y. Yin, J. A, and D. J. Chung, Characterization of cross-linked gelatin nanofibers through electrospinning, Macromolecular Research, 18, 137 (2010). crossref(new window)

A. J. Ribeiro, R. J. Neufeld, P. Amaud, and J. C. Chaumeil, Microencapsulation of lipophilic drugs in chitosan-coated alginate microspheres, International Journal of Pharmaceutics, 187, 115 (1999). crossref(new window)

E. B. Denkbas and M. Odabasi, Chitosan microspheres and sponges: Preparation and characterization, Journal of Applied Polymer Science, 76, 1637 (2000). crossref(new window)

X. Z. Shu and K. J. Zhu, A novel approach to prepare tripolyphosphate/ chitosan complex beads for controlled release drug delivery, International Journal of Pharmaceutics, 201, 51 (2000). crossref(new window)