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Cellular Protective Effects and Antioxidative Activity of Resveratrol
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  • Journal title : Applied Chemistry for Engineering
  • Volume 24, Issue 5,  2013, pp.483-488
  • Publisher : The Korean Society of Industrial and Engineering Chemistry
  • DOI : 10.14478/ace.2013.24.5.483
 Title & Authors
Cellular Protective Effects and Antioxidative Activity of Resveratrol
Jo, Na Rae; Park, Su Ah; Jeon, So Ha; Ha, Ji Hoon; Park, Soo Nam;
 
 Abstract
In this study, the cellular protective effect of resveratrol on oxidative damage and its antioxidative activity were investigated. The free radical-scavenging activity () of resveratrol was measured to be . The reactive oxygen species-scavenging activity () of resveratrol on the ROS generated in a system was investigated using the luminol-dependent chemiluminescence assay. Resveratrol displayed ROS scavenging activity, which is 9.6-fold higher than that of L-ascorbic acid () and had a more prominent cellular protective effect than (+)--tocopherol. When HaCaT cells were exposed to of UVB or treated with rose bengal, resveratrol protected the cells against oxidative stress in a concentration-dependent manner; however, it was unable to protect the cells when the damage was induced by 10 mM . These results indicate that resveratrol could be employed to improve and prevent the skin aging through its antioxidative and cellular protective activities.
 Keywords
resveratrol;antioxidative activity;cellular protective effect;oxidative damage;
 Language
English
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