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Enhanced Antimicrobial Activities and Physicochemical Characteristics of Isoliquiritigenin Encapsulated in Hydroxypropyl-β-Cyclodextrin
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  • Journal title : Applied Chemistry for Engineering
  • Volume 26, Issue 6,  2015, pp.719-724
  • Publisher : The Korean Society of Industrial and Engineering Chemistry
  • DOI : 10.14478/ace.2015.1107
 Title & Authors
Enhanced Antimicrobial Activities and Physicochemical Characteristics of Isoliquiritigenin Encapsulated in Hydroxypropyl-β-Cyclodextrin
Kim, Hae Soo; Im, Na Ri; Park, Soo Nam;
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Isoliquiritigenin (ILG) is a hydrophobic component in licorice and has a variety of pharmaceutical and biological activities. In this study, we prepared an isoliquiritigenin-hydroxypropyl--cyclodextrin (ILG/HP--CD) complex by freeze-drying method to enhance its water solubility. The complex was characterized by phase solubility studies, DSC, SEM, and 1H NMR. Antimicrobial activities against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) were evaluated by broth dilution method. The results showed that the stoichiometry of ILG/HP--CD complex was 1 : 1. The antimicrobial activity of ILG/HP--CD complex was higher than that of using free ILG against S. aureus and E. coli. Therefore, we suggest that ILG/HP--CD complex may be used as a natural antiseptic and could potentially replace synthetic preservatives in cosmetic and food industries.
isoliquiritigenin;hydroxypropyl--cyclodextrin;complexation;characterization;antimicrobial activity;
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