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Preparation of Valuable Compounds Encapsulated Polymer Nanoparticles with High Payload Using Core-crosslinked Amphiphilic Polymer Nanoparticles
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  • Journal title : Applied Chemistry for Engineering
  • Volume 27, Issue 1,  2016, pp.26-34
  • Publisher : The Korean Society of Industrial and Engineering Chemistry
  • DOI : 10.14478/ace.2015.1094
 Title & Authors
Preparation of Valuable Compounds Encapsulated Polymer Nanoparticles with High Payload Using Core-crosslinked Amphiphilic Polymer Nanoparticles
Kim, Nahae; Kim, Juyoung;
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 Abstract
In this study, core-crosslinked amphiphilic polymer (CCAP) nanoparticles prepared using a reactive amphiphilic polymer precursor (RARP) were used for preparing some valuable compounds encapsulated polymer nanoparticles with high payload through nanoprecipitation process. Various solvents (acetone, ethanol, and THF) having different polarity and CCAP nanoparticles prepared using different amphiphilicity were used for the preparation of -tocopherol encapsulated polymer nanoparticles to investigate their effects on the encapsulation efficiency, payload, nanoparticle size, and stability. CCAP dissolved in hydrophobic solvent, THF, could form -tocopherol encapsulated polymer nanoparticles dispersed in water with the high payload of -tocopherol and encapsulation efficiency. Because of their physically and chemically robust nano-structure originated from crosslinking of the hydrophobic core, CCAP nanoparticles could encapsulate -tocopherol with the high payload (33 wt%) and encapsulation efficiency (97%), and form 70 nm-sized stable nanoparticles in water.
 Keywords
amphiphilic polymer;nanoparticles;-tocopherol;nano-encapsulation;nanoprecipitation;
 Language
Korean
 Cited by
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