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Melanin: A Naturally Existing Multifunctional Material
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  • Journal title : Applied Chemistry for Engineering
  • Volume 27, Issue 2,  2016, pp.115-122
  • Publisher : The Korean Society of Industrial and Engineering Chemistry
  • DOI : 10.14478/ace.2016.1029
 Title & Authors
Melanin: A Naturally Existing Multifunctional Material
Eom, Taesik; Woo, Kyungbae; Shim, Bong Sup;
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 Abstract
Melanin is a common name used for a certain type of natural dark pigments existing in living organisms, particularly in human hair, eyes, and skin. The unique free radical scavenging effect of melanine could help protecting cells and tissues from harmful UV light. While their exact molecular structures in nature are not still well defined, their multifunctional properties including electrical and ionic conductivities, antioxidation, wet adhesion, and metal ion chelation, are highlighted for the potential applications in bioorganic electronics including biomedical sensors and devices. In this mini-review, we will discuss sources, synthesis methods, structures and multifunctional properties of melanin materials in addition to current research directions on a wide range of applications.
 Keywords
melanin;eumelanin;polydopamine;natural pigments;biocompatible;bioorganic electronics;
 Language
English
 Cited by
 References
1.
P. A. Riley, Melanin, Int. J. Biochem. Cell Biol., 29(11), 1235-1239 (1997). crossref(new window)

2.
M. d'Ischia, K. Wakamatsu, A. Napolitano, S. Briganti, J.-C. Garcia-Borron, D. Kovacs, P. Meredith, A. Pezzella, M. Picardo, T. Sarna, J. D. Simon, and S. Ito, Melanins and melanogenesis: Methods, standards, protocols, Pigment Cell Melanoma Res., 26(5), 616-633 (2013). crossref(new window)

3.
F. Solano, Melanins: Skin pigments and much more-types, structural models, biological functions, and formation routes, New J. Sci., 2014, 1-28 (2014).

4.
V. P. Grishchuk, S. A. Davidenko, I. D. Zholner, A. B. Verbitskii, M. V. Kurik, and Y. P. Piryatinskii, Optical absorption and luminescent properties of melanin films, Tech. Phys. Lett., 28(11), 896-898 (2002). crossref(new window)

5.
V. Capozzi, G. Perna, P. Carmone, A. Gallone, M. Lastella, E. Mezzenga, G. Quartucci, M. Ambrico, V. Augelli, P. F. Biagi, T. Ligonzo, A. Minafra, L. Schiavulli, M. Pallara, and R. Cicero, Optical and photoelectronic properties of melanin, Thin Solid Films, 511, 362-366 (2006).

6.
M. R. Powell and B. Rosenberg, The nature of the charge carriers in solvated biomacromolecules: DNA and water, Biopolymers, 9(11), 1403-1406 (1970). crossref(new window)

7.
J. E. McGinness, Mobility gaps: A mechanism for band gaps in melanins, Science, 177(4052), 896-897 (1972). crossref(new window)

8.
J. McGinness, P. Corry, and P. Proctor, Amorphous semiconductor switching in melanins, Science, 183(4127), 853-855 (1974). crossref(new window)

9.
P. B. Capelletti, P. R. Crippa, and N. Romeo, Electrical characteristics and electret behavior of melanin, ECS J. Solid State Sci. Technol., 126(7), 1207-1212 (1979).

10.
W. Osak, K. Tkacz, H. Czternastek, and J. Slawinski, I - V Characteristics and electrical conductivity of synthetic melanin, Biopolymers, 28(11), 1885-1890 (1989). crossref(new window)

11.
T. Ligonzo, M. Ambrico, V. Augelli, G. Perna, L. Schiavulli, M. A. Tamma, P. F. Biagi, A. Minafra, and V. Capozzi, Electrical and optical properties of natural and synthetic melanin biopolymer, J. Non-Cryst. Solids, 355(22-23), 1221-1226 (2009). crossref(new window)

12.
C. J. Bettinger, P. P. Bruggeman, A. Misra, J. T. Borenstein, and R. Langer, Biocompatibility of biodegradable semiconducting melanin films for nerve tissue engineering, Biomaterials, 30(17), 3050-3057 (2009). crossref(new window)

13.
M. Rozanowska, T. Sarna, E. J. Land, and T. G. Truscott, Free radical scavenging properties of melanin interaction of eu- and pheo-melanin models with reducing and oxidising radicals, Free Radic. Biol. Med., 26(5-6), 518-525 (1999). crossref(new window)

14.
C. C. Felix, J. S. Hyde, T. Sarna, and R. C. Sealy, Interactions of melanin with metal ions. Electron spin resonance evidence for chelate complexes of metal ions with free radicals, J. Am. Chem. Soc., 100(12), 3922-3926 (1978). crossref(new window)

15.
M. d'Ischia, A. Napolitano, A. Pezzella, P. Meredith, and T. Sarna, Chemical and structural diversity in eumelanins: Unexplored bio-optoelectronic materials, Angew. Chem. Int. Ed., 48(22), 3914-3921 (2009). crossref(new window)

16.
Y. Liu and J. D. Simon, The effect of preparation procedures on the morphology of melanin from the ink sac of Sepia officinalis, Pigment Cell Res., 16(1), 72-80 (2003). crossref(new window)

17.
M. d'Ischia, A. Napolitano, V. Ball, C.-T. Chen, and M. J. Buehler, Polydopamine and eumelanin: From etructure-property relationships to a unified tailoring strategy, Acc. Chem. Res., 47(12), 3541-3550 (2014). crossref(new window)

18.
J. P. Bothma, J. de Boor, U. Divakar, P. E. Schwenn, and P. Meredith, Device-quality electrically conducting melanin thin films, Adv. Mater., 20(18), 3539-3542 (2008). crossref(new window)

19.
M. I. N. da Silva, S. N. Deziderio, J. C. Gonzalez, C. F. O. Graeff, and M. A. Cotta, Synthetic melanin thin films: Structural and electrical properties, J. Appl. Phys., 96(10), 5803-5807 (2004). crossref(new window)

20.
Y. Liu, K. Ai, and L. Lu, Polydopamine and its derivative materials: Synthesis and promising applications in energy, environmental, and biomedical fields, Chem. Rev., 114(9), 5057-5115 (2014). crossref(new window)

21.
I. G. Kim, H. J. Nam, H. J. Ahn, and D.-Y. Jung, Electrochemical growth of synthetic melanin thin films by constant potential methods, Electrochim. Acta, 56(7), 2954-2959 (2011). crossref(new window)

22.
K. Kang, S. Lee, R. Kim, I. S. Choi, and Y. Nam, Electrochemically driven, electrode-addressable formation of functionalized polydopamine films for neural interfaces, Angew. Chem. Int. Ed., 51(52), 13101-13104 (2012). crossref(new window)

23.
Y. J. Kim, W. Wu, S.-E. Chun, J. F. Whitacre, and C. J. Bettinger, Biologically derived melanin electrodes in aqueous sodium-ion energy storage devices, Proc. Natl. Acad. Sci. USA, 110(52), 20912-20917 (2013). crossref(new window)

24.
M. L. Wolbarsht, A. W. Walsh, and G. George, Melanin, a unique biological absorber, Appl. Opt., 20(13), 2184-2186 (1981). crossref(new window)

25.
M. A. Rosei, L. Mosca, and F. Galluzzi, Photoelectronic properties of synthetic melanins, Synth. Met., 76(1-3), 331-335 (1996). crossref(new window)

26.
A. B. Mostert, B. J. Powell, F. L. Pratt, G. R. Hanson, T. Sarna, I. R. Gentle, and P. Meredith, Role of semiconductivity and ion transport in the electrical conduction of melanin, Proc. Natl. Acad. Sci. USA, 109(23), 8943-8947 (2012). crossref(new window)

27.
C.-T. Chen, V. Ball, J. J. de Almeida Gracio, M. K. Singh, V. Toniazzo, D. Ruch, and M. J. Buehler, Self-assembly of tetramers of 5,6-dihydroxyindole explains the primary physical properties of eumelanin: Experiment, simulation, and design, ACS Nano, 7(2), 1524-1532 (2013). crossref(new window)

28.
J. Wuensche, F. Cicoira, C. F. O. Graeff, and C. Santato, Eumelanin thin films: Solution-processing, growth, and charge transport properties, J. Mater. Chem. B, 1(31), 3836-3842 (2013). crossref(new window)

29.
D. Kai, M. P. Prabhakaran, G. Jin, and S. Ramakrishna, Biocompatibility evaluation of electrically conductive nanofibrous scaffolds for cardiac tissue engineering, J. Mater. Chem. B, 1(17), 2305-2314 (2013). crossref(new window)

30.
V. Gargiulo, M. Alfe, R. Di Capua, A. R. Togna, V. Cammisotto, S. Fiorito, A. Musto, A. Navarra, S. Parisi, and A. Pezzella, Supplementing pi-systems: eumelanin and graphene-like integration towards highly conductive materials for the mammalian cell culture bio-interface, J. Mater. Chem. B, 3(25), 5070-5079 (2015). crossref(new window)

31.
J. Borovansky, M. Elleder, Melanosome degradation: Fact or fiction, Pigment Cell Res., 16(3), 280-286 (2003). crossref(new window)

32.
D. J. Kim, K. Y. Ju, and J. K. Lee, The synthetic melanin nanoparticles having an excellent binding capacity of heavy metal ions, Bull. Korean Chem. Soc., 33(11), 3788-3792 (2012). crossref(new window)

33.
D. Wang, C. Chen, X. Ke, N. Kang, Y. Shen, Y. Liu, X. Zhou, H. Wang, C. Chen, and L. Ren, Bioinspired near-infrared-excited sensing platform for in vitro antioxidant capacity assay based on upconversion nanoparticles and a dopamine-melanin hybrid system, ACS Appl. Mater. Interfaces, 7(5), 3030-3040 (2015). crossref(new window)

34.
K. Shanmuganathan, J. H. Cho, P. Iyer, S. Baranowitz, and C. J. Ellison, Thermooxidative stabilization of polymers using natural and synthetic melanins, Macromolecules, 44(24), 9499-9507 (2011). crossref(new window)

35.
M. Araujo, R. Viveiros, T. R. Correia, I. J. Correia, V. D. B. Bonifacio, T. Casimiro, and A. Aguiar-Ricardo, Natural melanin: A potential pH-responsive drug release device, Int. J. Pharm., 469(1), 140-145 (2014). crossref(new window)

36.
M. P. da Silva, J. C. Fernandes, N. B. de Figueiredo, M. Congiu, M. Mulato, and C. F. de Oliveira Graeff, Melanin as an active layer in biosensors, AIP Adv., 4(3), 037120-1-8 (2014). crossref(new window)

37.
F. Bernsmann, B. Frisch, C. Ringwald, and V. Ball, Protein adsorption on dopamine-melanin films: Role of electrostatic interactions inferred from zeta-potential measurements versus chemisorption, J. Colloid Interface Sci., 344(1), 54-60 (2010). crossref(new window)

38.
T.-F. Wu and J.-D. Hong, Synthesis of water-soluble dopamine-melanin for ultrasensitive and ultrafast humidity sensor, Sens. Actuators B Chem., 224, 178-184 (2016). crossref(new window)

39.
M. D. Rubianes, A. Sanchez Arribas, E. Bermejo, M. Chicharro, A. Zapardiel, and G. Rivas, Carbon nanotubes paste electrodes modified with a melanic polymer: Analytical applications for the sensitive and selective quantification of dopamine, Sens. Actuators B Chem., 144(1), 274-279 (2010). crossref(new window)

40.
Y. J. Kim, W. Wu, S.-E. Chun, J. F. Whitacre, and C. J. Bettinger, Catechol-mediated reversible binding of multivalent cations in eumelanin half-cells, Adv. Mater., 26(38), 6572-6579 (2014). crossref(new window)

41.
W. Dong, Y. Wang, C. Huang, S. Xiang, P. Ma, Z. Ni, and M. Chen, Enhanced thermal stability of poly(vinyl alcohol) in presence of melanin, J. Therm. Anal. Calorim., 115(2), 1661-1668 (2014). crossref(new window)

42.
M. Xiao, Y. Li, M. C. Allen, D. D. Deheyn, X. Yue, J. Zhao, N. C. Gianneschi, M. D. Shawkey, and A. Dhinojwala, Bio-inspired structural colors produced via self-assembly of synthetic melanin nanoparticles, ACS Nano, 9(5), 5454-5460 (2015). crossref(new window)

43.
T.-F. Wu and J.-D. Hong, Dopamine-melanin nanofilms for biomimetic structural coloration, Biomacromolecules, 16(2), 660-666 (2015). crossref(new window)