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The Anti-Cancer Effect of β-Gluconsan Calcium on Oral Cancer Cell
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  • Journal title : Journal of dental hygiene science
  • Volume 15, Issue 6,  2015, pp.794-799
  • Publisher : the Korean Society of Dental Hygiene science
  • DOI : 10.17135/jdhs.2015.15.6.794
 Title & Authors
The Anti-Cancer Effect of β-Gluconsan Calcium on Oral Cancer Cell
Kim, Ji-Hye; Jung, Yun-Sook; Kim, Hye-Young; Lee, Young-kyun; Kim, Jae-Young; Choi, Youn-Hee; Song, Keun-Bae;
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 Abstract
In recent years, there has been a global trend toward the importance of natural extracts for the prevention and treatment of human diseases. -glucan is known to have anti-inflammatory activity, anti-cancer, and improvement of immune system. Polycan is purified -glucan from Aureobasidum pullulans SM-2001. The anti-cancer effects of -gluconsan calcium, polycan and calcium gluconate complex, were evaluated in human oral cancer YD-10B cells. YD-10B cells were cultured in the presence of 0, 0.5, 0.75, 1 mg/ml -gluconsan calcium for 48 hours. MTT assay, cell counting, and observation of cell morphology were conducted. The number of cells decreased and cell morphology changed in the 0.5 mg/ml of -gluconsan calcium. Almost all cells were dead in the 0.75 and 1 mg/ml. MTT assay showed a dose-dependent reduction in cell proliferation (p<0.05). These results indicate that -gluconsan calcium exhibiting anti-cancer effects in YD-10B cells through changes in cell morphology and cell death.
 Keywords
Anti-cancer;-gluconsan calcium;Oral cancer cells;
 Language
Korean
 Cited by
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