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Effect of Phenobarbital Sodium and 3-Methylcholanthrene on Metabolism of 14C-carbofuran in Rat
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 Title & Authors
Effect of Phenobarbital Sodium and 3-Methylcholanthrene on Metabolism of 14C-carbofuran in Rat
Rim, Yo-Sup; Han, Seong-Soo;
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In order to elucidate the effect of phenobarbital sodium (PB) and 3-methylcholanthrene (3-MC) on metabolism of insecticide carbofuran in rat. Carbofuran metabolites and its formation rates were determined when orally administered -carbofuran alone and its combination with PB or 3-MC to rat. -carbofuran administered orally, alone or in combination with PB or 3-MC, was secreted rapidly within 48 hrs. That is, 79.9 to 81.1% of the original radioactivity was secreted into the urine and 5.7 to 6.5% into the feces. The secretion rate was faster in the combined administration than that in carbofuran alone. Metabolites of carbofuran in main organs, urine, feces and blood of rat were largely 3-hydroxycarbofuran, 3-ketocarbofuran, 3-hydroxycarbofuran phenol, 3-ketocarbofuran phenol, and carbofuran phenol, the major ones being 3-hydroxycarbofuran and 3-ketocarbofuran, respectively, in all administrations of carbofuran alone, carbofuran+PB and carbofuran+3-MC. In addition, formation rate of the two major metabolites detected in the urine was 17.4% and 12.8%, respectively, when carbofuran alone was administered. Meanwhile, when carbofuran was administered with PB or 3-MC, they were 8.6% and 23.5, repectively. These results indicate that the oral administration of PB or 3-MC can reduce carbofuran toxicity by fastening and stimulating the carbofuran metabolism in rat.
carbofuran metabolism;phenobarbital sodium;3-methylcholanthrene;metabolites;insecticide carbofuran;
 Cited by
Researches Using Radio-labelled Insecticides in Korea,Lee, Kyu-Seung;

한국환경농학회지, 2007. vol.26. 4, pp.351-363 crossref(new window)
Chung, J. H. (1978) Hazards due to organic phosphorus pesticides, J. of Korean Medical Association 21, 359-364

Kuhr, R. J. (1968) Metabolism of carbamate insecticide chemicals in plants and insects, J. Agr. Food Chem. 18, 1023-1030 crossref(new window)

Agricultural Chemicals Industrial Association (1996) Agrochemicals Year Book, Munseon Planning Press, Seoul, Korea

Loewenstein, Y., Denarie, M., Zakut, H. and Soreq, H. (1993) Molecular dissection of cholinesterase domains responsible for carbamate toxicity, Chem. Biol. Interact. 87, 209-216 crossref(new window)

Lee, Y. D. (1988) Studies on the metabolism and fate of carbofuran in rice paddies, Ph. D. Thesis, Seoul National University, Seoul

Chaudhry, G. R. and Ali, A. N. (1988) Bacterial metabolism of carbofuran. Appl. Environ. Microbiol. 54, 1414-1419

Park, H. M. (1989) Studies on the resistance mechanism of the brown planthopper (Nilaparvata lugens STAL.) against fenobucarb, carbofuran and diazinon, Ph. D. Thesis, Seoul National University, Seoul

Metcalf, R. L., Fukuto, T. R., Collins, C., Borck, K., El-Aziz, S. A., Munoz, R. and Cassil, C. C. (1968) Metabolism of 2,2-dimethyl-2,3-dihydrobenzo-furanyl-7-N-methylcarbamate (furadan) in plants, insects, and mammals, J. Agr. Food Chem. 16, 300-311 crossref(new window)

Dorough, H. W. (1968) Metabolism of furadan(NIA-10242) in rats and houseflies, J. Agr. Food Chem. 16, 319-325 crossref(new window)

Lichtenstein, E. P., Kunstman J. L., Fuhremann, T. W. and Liang. T. T. (1979) Effects of atrazine on the toxicity; penetration and metabolism of carbofuran in the housefly, J. Econ. Entomol. 72, 780-788

Han, S. S. and Rim, Y. S. (1998) Effect of phenobarbital sodium and 3-methylcholanthrene on metabolism in vitro and toxicity of $^{14}C-carbofuran$ in rat, Kor. J. of Pesticide Science 2, 29-38

Rim, Y. S. (1997) Elucidation of the mechanisms on inhibition of the enzyme activities of rats by the insecticide carbofuran and detoxification by phenobarbital sodium or 3-methylcholanthrene, Ph. D. Thesis, Wonkwang University, Iksan, Jeonbug, Korea

Holden, E. R. and Cook, R. F. (1986) Pesticide Analytical Manual(vol. Ⅱ), FDA, USA

Kuhr, R. J. and Dorough, H. W. (1976) Carbamate Insecticides; Chemistry, Biochemistry, and Toxicology, CRC Press, USA