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Antibacterial and Therapeutic Effects of Houttuynia cordata Ethanol extract for Murine Salmonellosis
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 Title & Authors
Antibacterial and Therapeutic Effects of Houttuynia cordata Ethanol extract for Murine Salmonellosis
Kim, Dong-Hyeok; Lim, Jung-Ju; Lee, Jin-Ju; Jung, Won-Chul; Shin, Hyeon-Jin; Lee, Hu-Jang; Kim, Gon-Sup; Kim, Suk;
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 Abstract
Salmonellosis is a major bacterial zoonosis that causes a variety of disease syndromes, self-limited enteritis to fatal infection in animals and food-borne infection and typhoid fever in humans. Recently, the emergence of multidrug resistant strains of Salmonella spp. causes more serious problems in environment and public health. The present study was investigated the antibacterial effect of Houttuynia cordata ethanol extract(HCEE) for murine salmonellosis. In the cytotoxic effect of HCEE on RAW 264.7 cells, there was no detectable effect with any concentrations between 25 and 100 after 8 h incubation. The bacteriocidal effect of HCEE was not showed on a Salmonella enterica serovar Typhimurium(S. typhimurium). HCEE makes morphological change of the RAW 264.7 cells, and there was significant decreased bacterial uptake and intracellular replication within Salmonella infected cells. And further nitric oxide(NO) production of Salmonella infected RAW 264.7 cells with HCEE was decreased comparing to RAW 264.7 cells without HCEE until 8 h post infection. Oral administration of HCEE showed a therapeutic effect for S. typhimurium infected BALB/c mice. The mortality of HCEE treated mouse was 80% until 12 days, while that of HCEE untreated mouse was 100 % until 8 days after lethal dose of S. typhimurium infection. These data suggested that HCEE has a potency treatment for intracellular replicative pathogen including salmonellosis, brucellosis, tuberculosis, listeriosis etc., and the application of HCEE makes new strategies for safety medicine development without antibiotic resistance bacterial appearance and residue problem in food and solves the public health problem from antibiotic mis- and over use.
 Keywords
Salmonellosis;Houttuynia cordata ethanol extract;therapeutic effect;mouse;
 Language
Korean
 Cited by
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 References
1.
Tang, B. X., Duan, L. D., Wang, Y., Zhao, L. Z., Yu, Y. G. and Li, X. S. J. (2005) Shaoyang University (Natural Sciences) 2 (87), 80-81

2.
Zheng, Z. H., Dong, Z. H. and She, J. (1998) "Modern Research and Application of Traditional Chinese Medicines." Vol. 3. Xueyuan Press. Beijing. pp. 2983-3003

3.
Lu, H. M., Liang, Y. Z., Yi, L. Z. and Wu, X. J. (2006) Anti-inflammatory effect of Houttuynia cordata injection. J. Ethnopharmacol. 104, 245-249 crossref(new window)

4.
Lu, H., W, X., Liang, Y. and Zhang, J. (2006) Variation in chemical composition and antibacterial activities of essential oils from two species of Houttuynia THUNB. Chem. Pharm. Bull. 54(7), 936-40 crossref(new window)

5.
Iqbal, M., Ohen, R. I, Marzouk, K. and Liu, S. F., (2002) Time course of nitric oxide, peroxynitrite, and antioxidants in the endotoxemic heart. Crit. Care. Med. 30, 1291-1296 crossref(new window)

6.
Berendji, D., Kolb-Bachofen, V., Meyer, K. L. and Kroncke, K.D., (1999) Influence of nitric oxide on the intracellular reduced glutathione pool: different cellular capacities and strategies to encounter nitric oxide-mediated stress. Free Radic. Biol. Med. 27, 773-780 crossref(new window)

7.
Park, E., Kum, S., Wang, C., Park, S. Y., Kim, B. S. and Schuller-Levis, G. (2005) Anti-inflammatory activity of herbal medicines: inhibition of nitric oxide production and tumor necrosis factor-alpha secretion in an activated macrophage-like cell line. Am. J. Chin. Med. 33(3), 415-424 crossref(new window)

8.
Li, G. Z., Chai, O.H., Lee, M.S., Han, E.H., Kim H.T. and Song C.H. (2005) Inhibitory effects of Houttuynia cordata water extracts on anaphylactic reaction and mast cell activation. Biol. Pharm. Bull. 28(10), 1864-1868 crossref(new window)

9.
Cherayil, B. J. and Antos, D. (2001) Inducible nitric oxide synthase and Salmonella infection. Microbes. Infect. 3, 771-776 crossref(new window)

10.
Nathan, C. and Shiloh, M. U. (2000) Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc. Natl. Acad. Sci. 97, 8841-8848

11.
Valle, E. and Guiney, D.G. (2005) Characterization of Salmonella-induced cell death in human macrophagelike THP-1 cells. Infect. Immun. 73, 2835-2840 crossref(new window)

12.
Miriagou, V., Carattoli A. and Fanning S. (2006) Antimicrobial resistance islands: resistance gene clusters in Salmonella chromosome and plasmids. Microbes. Infect. 8(7), 1923-30 crossref(new window)

13.
MacFarlane, A. S., Schwacha, M. G. and Eisenstein T. K. (1999) In vivo blockage of nitric oxide with aminoguanidine inhibits immunosuppression induced by an attenuated strain of Salmonella typhimurium, potentiates Salmonella infection, and inhibits macrophage and polymorphonuclear leukocyte influx into the spleen. Infect. Immun. 67, 891-898

14.
Umezawa, K., Akaike, T., Fujii, S., Suga, M., Setoguchi, K., Ozawa, A. and Maeda, H. (1997) Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice. Infect. Immun.,65, 2932-2940

15.
Kim, S., Watarai, M., Kondo Y., Erdenebaatar, J., Makino S. and Shirahata T. (2003) Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Infect. Immun. 3020-3027 crossref(new window)

16.
Margaret, W., Nilofer, Q., Nancy, S. and Gary, S. (2001) High levels of nitric oxide production decrease early but increase late survival of Brucella abortus in macrophages. Microbial Pathogenesis 31,221-230 crossref(new window)

17.
Oumzil, H., Ghoulami, S., Rhajaoui, M., Ilidrissi, A., Fkih-Tetouani, S., Faid, M. and Benjouad A. (2002) Antibacterial and antifungal activity of essential oils of Mentha suaveolens. Phytother Res. 16, 727-731 crossref(new window)

18.
Martins, A. P., Salgueiro, L. R., Goncalves, M. J., Vila, R., Tomi, F., Adzet, T. and Casanova J. (2000) Antimicrobial activity and chemical composition of the bark oil of Croton stellulifer, an endemic species from S. Tome e Príncipe. Planta Med. 66, 647-650 crossref(new window)

19.
Foster, J. W. and Spector M. P. (1995) How Salmonella survive against the odds. Annu. Rev. Microbiol. 49, 145-174 crossref(new window)

20.
Lu, S., Manges, A. R., Xu, Y., Fang, F. C. and Riley L. W. (1999) Analysis of virulence of clinical isolates of Salmonella enteritidis in vivo and in vitro. Infect. Immun. 67, 5651-5657

21.
Kwon, K. B., Kim, E. K., Shin, B. C., Seo, E. A., Yang, J. Y. and Ryu, D. G., (2003) Herba houttuyniae extract induces apoptotic death of human promyelocytic leukemia cells via caspase activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Exp. Mol. Med. 35, 91-97 crossref(new window)

22.
Guiney, D. G. (2005) The role of host cell death in Salmonella infections. Curr. Top. Microbiol. Immunol. 2005; 289, 131-50 crossref(new window)

23.
Chakravortty, D. and Hensel, M. (2003) Inducible nitric oxide synthase and control of intracellular bacterial pathogens. Microbes. Infect. 5, 621-627 crossref(new window)

24.
Macmicking, J. D., Xie, Q. W. and Nathan, C. (1997) Nitric oxide and macrophage function. Annu. Rev. Immunol. 15, 323-350 crossref(new window)

25.
Xie, Q. W., Cho, H. J., Calaycay, J., Mumgord , R. A., Swiderek, K. M., Lee, T. D., Ding, A., Troso, T. and Nathan, C. (1992) Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256, 225-228 crossref(new window)

26.
Garci-a-del Portillo, F. (1996) Interaction of Salmonella with lysosomes of eukaryotic cells. Microbiologia. 12(2), 259-66