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Oral Single-dose Toxicity Studies on Germanium-fortified Lettuce, in Mouse
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 Title & Authors
Oral Single-dose Toxicity Studies on Germanium-fortified Lettuce, in Mouse
Kim, Jong-Jin; Choi, Ji-Na; Cho, Ju-Sik; Heo, Jong-Soo; Yee, Sung-Tae;
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 Abstract
Single-dose toxicity test of germanium-fortified lettuce was investigated in mice. Both sexes of C57BL/6 mice were orally administered once at a dose of 2,000 mg/kg. No death, clinical signs and pathological findings related to the treatment were observed. In addition, no significant changes in feed consumption and body weight gain were obtained during the treatment period, in spite of day-to-day fluctuation of water consumption. There were no considerable changes in hematology and serum biochemistry, except a significant decrease in GPT, GOT and LDH. Several alterations were observed in organ weight and blood biochemistry, including thymus, ovaries, heart, kidney and platelet in male or female mice. The ability of spleen cells proliferation was almost same level as shown in control group. However the population of B cells, helper T cells and cytotoxic T cells was not comparably changed in all groups. Taken together, it is suggested that single oral dose of germanium-fortified lettuce to C57BU6 mice did not cause apparent toxicological change at the dose of 2,000 mg/kg body weight.
 Keywords
Germanium;Lettuce;;;Toxicity;B cells;T cells;
 Language
Korean
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 References
1.
Jang, J. J., Cho, K. J., Lee, S. and Bae. J. H.(1991) Modifying responses of allyl sulfide, indole-3-carbinol and germanium ina a rat multi-organ carcinogenesis model. Carcinogenesis 12(4), 691-695 crossref(new window)

2.
Mochizuki, Hand Kada, T. (1982) Antimutagenic effect of Ge-132 on v-ray-induced mutation in Escherchia coli B/rWP2 trp-. Int. J. Radiat. Biol. 42(6), 653-659 crossref(new window)

3.
Suzuki, F., Brutkiewicz, R. R. and Pollard, R. B. (1986) Cooperation of lymphokine (s) and marcophages in expression of antitumor actibity of carboxyethylgermanium (Ge-132). Antitumor Res. 62(2), 177-182

4.
Aso, H., Suzuki, F., Yamaguchi, T., Hayashi, Y., Ebina, T. and Ishida, N. (1985) Induction of interferone and activation of NK cells and macrophages in mice by oral administration of Ge-12, and organic germanium compound. Microbiol. Immunol. 29(1), 65-74 crossref(new window)

5.
Dimartion, M. J. (1986) Antiarthritic and immunoregulatory activity of spirogermaium. J.Pharmacil. Exp. Ther. 236(1), 103-110

6.
Sasaki, K., Ishikawa, M., Monma, K. and takayanagi, G. (1984) Effect of carboxyethylgermanium sesquioxide (Ge-132) on the acute inflammation and $CCl_4$ induced hepatic damage in mice. pharmacometrics 27(6), 1119-1131

7.
Lee, H. M. and Chung, Y. (1991) Effect of organic germanium on metallothionnein inductin in liver and kindey of cadmium and mercury intoxicated rats. Yakhak Hoeji 35(2), 99-110

8.
Ho, C. C., Cherm, Y. F. and lin, M. T. (1990) Effects of organogermanium compound 2-carboxyethylgermanium sesquioxide on cardiovascular function motor actibity in rats. Pharmacology 41, 286-291 crossref(new window)

9.
Kehlbeck, H. (1983) New germanium containing yeast for medicinal and veterinary use. Deutsch patent DE. 3345211

10.
Nobohiro, W., Osaumu, I., Dakuro, K. and Koichi, Y. (1980) New approaches to using spent brewer's yeast. ASBC J. 38, 5

11.
Wei, X. S. (1992) Effect of yeast on bioenrichment of germanium. Food Sci. 149, 49-54

12.
Lee, S. T., Lee, Y. H., Choi, Y. J., Lee, S. D., Lee, C. Hand Heo, J. s. (2005) Growth characteristics and germanium absorption of rice plant with different germanium concentration in soil. Korean J. Environ. Agric. 24(1), 40-44 crossref(new window)

13.
Lee, S. T., Lee. Y. H., Bhan, K. N., Seo, D. C. and Hea, J. S. (2005) Crowth characteristics and germanium absorption in Lettuce with differnt concentrations of germanium in soil. Korean J. Environ. Agric. 24(4), 404-408 crossref(new window)

14.
Lee, G. P., Park, H. S., Won, J. H. and Park, K. W. (2005) Effect of $CeO_2$concentration on hydroponically-grown lettuce (Lactuca sativa). J. Kor. Soc. Hort. Sci. 46(2), 113-118

15.
Han, S. S., Rim, Y. S. and Jeong, J. H. (1996) Growth characteristics and germanium absorption of soybean sprout cultured with aqueous solution of organogerrnanium. Agric. Chem. Biotech. 39(1), 39-43

16.
Chang, E, J. and Oh, H. I. (2005) Effects of addition of inorganic germanium, $CeO_2$on the Growth, germaium and saponin contents of ginseng adventitious root in submerged culture. J. Ginseng Res. 29(3), 145-151 crossref(new window)

17.
Obra, K., Saito, T., Sato, H., Yamakage, K., Watanabe, T., Kakizawa, M, Tsukamoto, T., Kobayashi, K., Hongo, M. and Yoshinaga, K. (1991) Germanium poisoning; clinical symptoms and renal damage caused by long-term intake of germanium. Japanese J. Medicine 30(1), 67-72 crossref(new window)

18.
Iijima, M., Mugishima, M., Takeuchi, M., Uchiyama, S., Kobayashi, I. and Maruyama, S. (1990) A case of inorganic germanium poisoning with peripheral and cranial nephropathy. myopathy and autonomic dysfunction 42(9), 851-856

19.
Sanai, T., Oochi, S., Osato, S., Kiyama, S., Komota, T., Onoyama, K., (1990) Subacute nephrotoxicity of germanium dioxide in the experimental animal. Toxicol Appl Pharmacol. 103(2):345-53 crossref(new window)

20.
Sanai, T., Onoyama, K., Osato, S., Motomura, K., Oochi, N., Oh, Y., Okuda, S., Takaichi, S., Fujishima, M., (1991) Dose dependency of germaniumdioxide-induced nephrotoxicity in rats. Nephron. 57(3):349-54 crossref(new window)

21.
Higuchi, I., Takahashi, K., Nakahara, K., Izumo, S., Nakagawa, M., Osame, M., (1991) Experimental germanium myopathy. Acta Neuropathol. 82(1):55-9 crossref(new window)

22.
Matsumuro, K., Izumo, S., Higuchi, I., Ronquillo, AT., takahashi, K., Osame, M., (1993) Experimental germanium-dioxide-induced nephropathy in rats. Acta Neuropathol. 86(6):547-53 crossref(new window)

23.
Schauss, AG., (1991) Nephrotoxicity in humans by the ultratrace element germanium. Ren Fail. 13(1):1-4 crossref(new window)

24.
Nagata, N., Yoneyama, T., Yanagida, K., Ushio, K., Yanagihara, S., Matsubara, G., Eishi, T., (1985) Accumulation of germanium in the Tissues of a long-term user of germanium preparation died of acute renal failure. J Toxicol Sci. 1 (4):333-41

25.
Sugiya, Y., Sakamaki, S. and Satoh, H., (1986) Reversibility study in rats after two month's oral administration of carboxyethylgermanium sesquioxide (Ge-132) Pharmacometrics. 31(6), 1191-1200

26.
Sugiya, Y., Sakamaki, S., Sugita, T., Abo, Y., and Satoh, H., (1986) Subacute oral toxicity of carboxyethylgermanium sesquioxide(Ge-132) in rats 31(6), Phannacometrics. 1181-1190

27.
Sugiya, Y., Yoshida, K., Sakamaki, S., Eda, K., and Satoh, H., (1986) Reproductive and teratogenic studies of carboxyethylgerrnanium sesquioxid (Ge-132) (2) Teratogenesis study in rats by intravenous administration. Phannacometrics. 32(1), 123-138

28.
Nagai, H., Hasegawa, K., and Shimpo, K., (1980) Reproductive study of rats intraperitonealy treated with carboxyethylgermanium sesquioxide(Ge-132). Pharmacometrics. 20(2), 271-280

29.
Nagata, T., Aramaki, Y., Enomoto, M., Isaka, H., and Otuka, J., (1978) Chronic intravenously toxicity study with carboxyethylgermanium sesquioxide in beagle-dog. Pharmacometrics. 16, 671-682

30.
Seo, K. W., Lee, K. M., Oh, M. H. and Kim, H. J., (1997) Acute toxicity of OrganogermaniUffi, Ge-132 in Rats and Mice. J. Fd Hyg. Safety. 12(4): 271-276

31.
Song, S. W., Jung, Wand Hong, D. H., (2006) Single Dose Toxicity Studies of STB-HO-BM in Rats and Dogs. J. Toxicol. Pub. Health. 153-156

32.
Lee, J. S., Park, J. I., Kim, S. H., Park, S. H., Kang, S. K., Park, C. B., Sohn, T. U., Jang, J. Y., Kang, J. K. and Kim, Y. B., (2004) Oral single- and repeateddose toxicity studies on GERANTI BIO-GE YEAST$^{\circledR}$ organic germanium fortified yeast, in rats. The Journal of Toxicological Sciences. 541-553

33.
Lee, J. S., Park, J. I., Kim, S. H., Lee, H. Y., Hwang, Z. Z., Park, C. B., Sohn, T. U., Shin, S. H., Kang, J. K and Kim, Y. B. (2004) Oral single-and repeated-dose toxicity studies on GERANTI BIO-GE YEAST$^{\circledR}$, organic germanium fortified yeast, in dogs. The Journal of Toxicological Sciences. 555-569

34.
Joo, S. S., Won, T. J., Lee, Y. J., Kim, M. J., Park, S. Y., Lee, S. H., Hwang, K. W. and Lee, D. I. (2006) Effect of Geranti Bio-Ge Yeast, a dried yeast containing biogerrnnium, on the production of antibodies by B cells. Immune Network. 6(2), 86-92 crossref(new window)

35.
백대헌, 정진욱, 손창욱, 강종구. (2007) 게르마늄 강화효모의 마우스에서의 암세포 억제 및 대식세포, NK 세포, B 세포의 활성화에 관한 연구. Kor. J. Microbiol. Biotechnol. 35(2), 118-127