Advanced SearchSearch Tips
Pharmacokinetic Characterization of Nano-emulsion Vitamin A, D and E (LaVita) in Rats
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Pharmacokinetic Characterization of Nano-emulsion Vitamin A, D and E (LaVita) in Rats
Lee, Young-Ju; Kwon, Min; Kim, Tae-Hwan; Kim, Kyun; Jeong, Sang-Hee; Chang, Hee-Ra;
  PDF(new window)
BACKGROUND: Bioavailability enhancement by solubilization of lipophilic drugs in nano-emulsion has been reported and it may be useful in pharmaceutical and nutraceutical products. This study was performed to compare in vivo bioavailability of nano-emulsion formulation with that of the general product as control. METHODS AND RESULTS: The pharmacokinetics assessment of Vitamin A, D and E complex of nanoemulsion formulation (LaVita), in comparison to the general product, was performed in the male rat plasma by a single oral dose at 20 mL/kg body weight (n=3/group). For nano-emulsion formulation (LaVita), of vitamin A and E in plasma were much higher and the area under the curve (AUC) of vitamin A, D and E were 14-63% higher, and the half-life of vitamin E was 2-fold longer than the general product. According to statistical analysis, each of vitamin A, D & E was significantly higher (p<0.01, 0.05 and 0.01, respectively) than that of general product. Half-life of vitamin A was significantly higher (p<0.01) and AUC of vitamin A and D were also significantly higher than the general product. CONCLUSION(s): Considering significant increment of and AUC, LaVita made of nano-emulsion could be more effective the absorption rate and extent for bioavailability of vitamin A, D & E than those of general product.
Bioavailability;Fat-soluble vitamin;Nanoemulsion;Pharmacokinetics;Plasma;
 Cited by
Characteristics of Fertility of Cucumber Cultivated Soils at Controlled Horticulture in Chungnam Province,;;;;;;;

한국토양비료학회지, 2014. vol.47. 4, pp.262-268 crossref(new window)
Nanoemulsions for food fortification with lipophilic vitamins: Production challenges, stability, and bioavailability, European Journal of Lipid Science and Technology, 2017, 119, 7, 1500539  crossref(new windwow)
Brusewitz, C., Schendler, A., Funke, A., Wagner, T., Lipp, R., 2007. Novel poloxamer-based nanoemulsions to enhance the intestinal absorption of active compounds, Int. J. Pharm. 329, 173-181. crossref(new window)

Burton, G.W., Ingold, K.U., Foster, D.O., Cheng, S.C., Webb, A., Hughes, L., Lusztyk, Ewa., 1988. Comparison of free $\alpha$-Tocopherol and $\alpha$-Tocopheryl Acetate as Sources of Vitamin E in Rats and Humans, Lipid 23, 834-840. crossref(new window)

Burton, G.W., Traber, M.G., 1990. Vitamin E: Antioxidant activity, Biokinetics, and Bioavailability, Annu. Rev. Nutr. 10, 357-382. crossref(new window)

Gomis, D,B,, Escotet, A.V.J., Fidalgo, A.L.E., Gutierrez, A.M.D., 1994. Simulataneous determination of vitamins D3, E and K1 and retinyl palmitate in cattle plasma by liquid chromatography with a narrow- bore column, J. Chromatogr. B 660, 49-55. crossref(new window)

Gonzalez, M.J., 1990. Serum Concentrations and Cellular Uptake of Vitamin E, Med. Hypotheses 32, 107-110. crossref(new window)

Gutierrez, J.M., Gonzalez, C., Maestro, A., Sole, I., Pey, C.M., Nolla, J., 2008. Nano-emulsions: New applications and optimization of their preparation. Curr. Opin. Coll. Int. Sci. 13, 245-251. crossref(new window)

Hatanaka, J., Chikamori, H., Sato, H., Uchida, S., Debari, K., Onoue, S., Yamada, S., 2010. Physicochemical and pharmacological characterization of $\alpha$-tocopherol-loaded nano-emulsion syatem. Int. J. Pharm. 396, 188-193. crossref(new window)

Hidiroglou, M., Ivan, M., Toutain, P.L., 1994. Metabolism of Tritiated D-$\alpha$-Tocopherol and D-$\alpha$ -Tocophery Succinate in Intraruminally Dosed Sheep. J. Anim. Sci. 72, 2124-2130. crossref(new window)

Heudi, O., Trisconi, M.J., Blake, C.J., 2004. Simultaneous quantification of Vitamins A, D3, and E in fortified infant formulae by liquid chromatography- mass spectrometry. J. Chromatogr. A 1022, 115-123. crossref(new window)

Kang, H.S., Kwon, S.S., Kim, B.H., Lee, B.R., Kang, K.H., Hong, J.E., Han, S.H., Chang, I.S., 2002. Nanoemulsion as a Vitamin E Acetate Carrier to Enhance Infiltration into Oral Mucous Membrane, J. Ind. Eng. Chem. 8, 348-353.

Lee, S.J., Choi, S.J., Li, Y., Decker, E.A., 2011. McClements DJ. Protein-Stabilized Nanoemulsions and Emulsions: Comparison of Physicochemical Stability, Lipid Oxidation, and Lipase Digestibility, J. Agric. Food. Chem. 59, 415-427. crossref(new window)

Mendoza, B.R., Pons, S.M., Bargallo, A.I.C., Lopez-Sabater, M.C., 2003. Rapid determination by reversed-phase high-performance liquid chromatography of Vitamin A and E in infant formulas, J. Chromatogr. A 1018, 197-202. crossref(new window)

Solans, C., Izquierdo, P., Nolla, J., Azemar, N., Garcia-Celma, M.J., 2005. Nano-emulsion, Curr. Opin. Coll. Int. Sci. 10, 102-110. crossref(new window)

Tadros, T., Izquierdo, P., Esquena, J., Solans, C., 2004. Formation and stability of nano-emulsions, Adv. Colloid. Interface. Sci. 108-109, 303-318. crossref(new window)

Taha, E., Ghorab, D., Zaghloul, A.A., 2007. Bioavailability Assessment of Vitamin A Self-Nanoemulsified Drug Delivery Systems in Rats: A Comparative Study, Med, Princ, Pract. 16, 355-359. crossref(new window)