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α-Glucosidase Inhibitory Effect of Vicine and α-Eleostearic Acid from the Seeds of Momordica charantia
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 Title & Authors
α-Glucosidase Inhibitory Effect of Vicine and α-Eleostearic Acid from the Seeds of Momordica charantia
Yuk, Heung Joo; Noh, Geon Min; Choe, Jeong Sook; Kwon, Oh Kyung; Hong, Su Young; Kang, Sang Soo; Cho, Kye Man; Park, Dong Sik;
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BACKGROUND: Momordica charantia (MC) have been used in various parts of the world to treat diabetes. Despite the highest effects of phytochemicals than any other part of the plant, the main components of seed of MC grown in Korea and their properties have not been studied extensively. METHODS AND RESULTS: The seeds of MC were extracted into five different polarity solvents: 30%, 50%, 70%, 95% ethanol and distilled water. The 95% ethanol extract showed the most potent inhibition () against -glucosidase. To investigate the compounds responsible for this effect, activity guided fractionation of MC seeds by chromatography yielded two phytochemicals which were confirmed as vicine (1) and -eleostearic acid (2) based on their NMR and ESI-MS spectroscopic data. Among them, -eleostearic acid (2) possessed potent -glucosidase inhibitory activities with values from . CONCLUSION: Collectively, the results from this present study strongly suggest that both extract and -eleostearic acid (2) have potent -glucosidase inhibitory activity. Furthermore, -eleostearic acid (2) as the most active -glucosidase inhibitor was proven to be present in high quantities in the MC seeds by a HPLC chromatogram.
Bitter melon;-Eleostearic acid;-Glucosidase;Momordica charantia;Vicine;
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