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Temperature and pH-Responsive Release Behavior of PVA/PAAc/PNIPAAm/MWCNTs Nanocomposite Hydrogels
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  • Journal title : Carbon letters
  • Volume 13, Issue 3,  2012, pp.173-177
  • Publisher : Korean Carbon Society
  • DOI : 10.5714/CL.2012.13.3.173
 Title & Authors
Temperature and pH-Responsive Release Behavior of PVA/PAAc/PNIPAAm/MWCNTs Nanocomposite Hydrogels
Jung, Gowun; Yun, Jumi; Kim, Hyung-Il;
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A drug delivery system (DDS) was prepared with a temperature and pH-responsive hydrogel. Poly(vinyl alcohol) (PVA)/poly(acrylic acid) (PAAc)/poly(N-isopropylacrylamide) (PNIPAAm)/multi-walled carbon nanotube (MWCNT) nanocomposites were prepared by radical polymerization for the temperature and pH-responsive hydrogels. MWCNTs were employed to improve both the thermal conductivity and mechanical properties of the PVA/PAAc/PNIPAAm/MWCNT nanocomposite hydrogels. Various amounts of MWCNTs (0, 0.5, 1 and 3 wt%) were added to the nanocomposite hydrogels. PVA/PAAc/PNIPAAm/MWCNT nanocomposite hydrogels were characterized with a scanning electron microscope. The mechanical properties were measured with a universal testing machine. Swelling and releasing properties of nanocomposite hydrogels were investigated at various temperatures and pHs. Temperature and pH-responsive release behavior was found to be dependent on the content of MWCNTs in nanocomposite hydrogels.
carbon nanotubes;temperature-responsive;pH-responsive;hydrogel;drug release;
 Cited by
Controlled release of highly water-soluble antidepressant from hybrid copolymer poly vinyl alcohol hydrogels, Polymer Bulletin, 2014, 71, 1, 31  crossref(new windwow)
Phipps JB, Scott ER, Gyory JR, Padmanabhan RV. Iontophoresis. In: Swarbrick J, Boylan JC, eds. Encyclopedia of Pharmaceutical Technology. 2nd ed., Marcel Dekker, New York, 1573 (2002).

Davidson A, Al-Qallaf B, Das DB. Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability. Chem Eng Res Des, 86, 1196 (2008). http:// crossref(new window)

Carson HJ, Knight LD, Dudley MH, Garg U. A fatality involving an unusual route of fentanyl delivery: chewing and aspirating the transdermal patch. Legal Med, 12, 157 (2010). http://dx.doi. org/10.1016/j.legalmed.2010.03.001. crossref(new window)

Schulz M, Fussnegger B, Bodmeier R. Influence of adsorbents in transdermal matrix patches on the release and the physical state of ethinyl estradiol and levonorgestrel. Eur J Pharm Biopharm, 77, 240 (2011). crossref(new window)

Hirokawa Y, Tanaka T. Volume phase transition in a nonionic gel. J Chem Phys, 81, 6379 (1984). crossref(new window)

Hoffman AS. Applications of thermally reversible polymers and hydrogels in therapeutics and diagnostics. J Controlled Release, 6, 297 (1987). crossref(new window)

Don TM, Chen HR. Synthesis and characterization of AB-crosslinked graft copolymers based on maleilated chitosan and N-isopropylacrylamide. Carbohydr Polym, 61, 334 (2005). http://dx.doi. org/10.1016/j.carbpol.2005.05.025. crossref(new window)

Tanaka T. Phase transitions in gels and a single polymer. Polymer, 20, 1404 (1979). 7. crossref(new window)

Yan Q, Hoffman AS. Synthesis of macroporous hydrogels with rapid swelling and deswelling properties for delivery of macromolecules. Polymer, 36, 887 (1995). 3861(95)93123-4. crossref(new window)

Khare AR, Peppas NA. Swelling/deswelling of anionic copolymer gels. Biomaterials, 16, 559 (1995). 9612(95)91130-q. crossref(new window)

Ilavsky M. Phase transition in swollen gels. 2. Effect of charge concentration on the collapse and mechanical behavior of polyacrylamide networks. Macromolecules, 15, 782 (1982). http://dx.doi. org/10.1021/ma00231a019. crossref(new window)

Heskins M, Guillet JE. Solution properties of poly(N-isopropylacrylamide). J Macromol Sci A: Chem, 2, 1441 (1968). http:// crossref(new window)

Tanaka Y, Kagami Y, Matsuda A, Osada Y. Thermoreversible transition of tensile modulus of hydrogel with ordered aggregates. Macromolecules, 28, 2574 (1995). ma00111a062. crossref(new window)

Aoki T, Kawashima M, Katono H, Sanui K, Ogata N, Okano T, Sakurai Y. Temperature-responsive interpenetrating polymer networks constructed with poly(acrylic acid) and poly(N,N-dimethylacrylamide). Macromolecules, 27, 947 (1994). http://dx.doi. org/10.1021/ma00082a010. crossref(new window)

Hassan C, Peppas N. Structure and applications of poly(vinyl alcohol) hydrogels produced by conventional crosslinking or by freezing/thawing methods. Adv Polym Sci, 153, 37 (2000). http:// crossref(new window)

Lee JW, Kim SY, Kim SS, Lee YM, Lee KH, Kim SJ. Synthesis and characteristics of interpenetrating polymer network hydrogel composed of chitosan and poly(acrylic acid). J Appl Polym Sci, 73, 113 (1999). 4628(19990705)73:1<113::aid-app13>;2-d. crossref(new window)

Chen L, Xie H. Surfactant-free nanofluids containing double- and single-walled carbon nanotubes functionalized by a wet-mechanochemical reaction. Thermochim Acta, 497, 67 (2010). http://dx.doi. org/10.1016/j.tca.2009.08.009. crossref(new window)

Yun J, Im JS, Lee YS, Kim HI. Electro-responsive transdermal drug delivery behavior of PVA/PAA/MWCNT nanofibers. Eur Polym J, 47, 1893 (2011). 2011.07.024. crossref(new window)

Park OK, Jeevananda T, Kim NH, Kim Si, Lee JH. Effects of surface modification on the dispersion and electrical conductivity of carbon nanotube/polyaniline composites. Scripta Mater, 60, 551 (2009). crossref(new window)

Jeon S, Yun J, Lee YS, Kim HI. Preparation of poly(vinyl alcohol)/ poly(acrylic acid)/TiO2/carbon nanotube composite nanofibers and their photobleaching properties. J Ind Eng Chem, 18, 487 (2012). crossref(new window)