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Temperature and pH-Responsive Release Behavior of PVA/PAAc/PNIPAAm/MWCNTs Nanocomposite Hydrogels
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  • Journal title : Carbon letters
  • Volume 13, Issue 3,  2012, pp.173-177
  • Publisher : Korean Carbon Society
  • DOI : 10.5714/CL.2012.13.3.173
 Title & Authors
Temperature and pH-Responsive Release Behavior of PVA/PAAc/PNIPAAm/MWCNTs Nanocomposite Hydrogels
Jung, Gowun; Yun, Jumi; Kim, Hyung-Il;
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 Abstract
A drug delivery system (DDS) was prepared with a temperature and pH-responsive hydrogel. Poly(vinyl alcohol) (PVA)/poly(acrylic acid) (PAAc)/poly(N-isopropylacrylamide) (PNIPAAm)/multi-walled carbon nanotube (MWCNT) nanocomposites were prepared by radical polymerization for the temperature and pH-responsive hydrogels. MWCNTs were employed to improve both the thermal conductivity and mechanical properties of the PVA/PAAc/PNIPAAm/MWCNT nanocomposite hydrogels. Various amounts of MWCNTs (0, 0.5, 1 and 3 wt%) were added to the nanocomposite hydrogels. PVA/PAAc/PNIPAAm/MWCNT nanocomposite hydrogels were characterized with a scanning electron microscope. The mechanical properties were measured with a universal testing machine. Swelling and releasing properties of nanocomposite hydrogels were investigated at various temperatures and pHs. Temperature and pH-responsive release behavior was found to be dependent on the content of MWCNTs in nanocomposite hydrogels.
 Keywords
carbon nanotubes;temperature-responsive;pH-responsive;hydrogel;drug release;
 Language
English
 Cited by
1.
Liberation of drugs from multi-wall carbon nanotube carriers, Journal of Controlled Release, 2013, 169, 1-2, 126  crossref(new windwow)
2.
Controlled release of highly water-soluble antidepressant from hybrid copolymer poly vinyl alcohol hydrogels, Polymer Bulletin, 2014, 71, 1, 31  crossref(new windwow)
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