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Optimization of Fermentation Medium for Glycyrrhizin Biotransformation to Monoglucuronyl-glycyrrhetinic Acid by Plackett-Burman and Box-Behnken Design
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  • Journal title : Korean Chemical Engineering Research
  • Volume 53, Issue 3,  2015, pp.321-326
  • Publisher : The Korean Institute of Chemical Engineers
  • DOI : 10.9713/kcer.2015.53.3.321
 Title & Authors
Optimization of Fermentation Medium for Glycyrrhizin Biotransformation to Monoglucuronyl-glycyrrhetinic Acid by Plackett-Burman and Box-Behnken Design
Quan, Yanling; Wang, Lin; Liu, Yisheng; Cong, Jingxiang; Xie, Shengquan; Wu, Xiuhong;
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 Abstract
Plackett-Burman (PB) and Box-Behnken (BB) experimental designs were used to optimize fermentation variables for the biotransformation of glycyrrhizin (GL) to monoglucuronyl-glycyrrhetinic acid (MGGA). The PB design was first used to screen the important factors among the medium variables. The steepest ascent method was used to approach the optimum range for each of these factors. The BB design was finally used to analyze the response surfaces of the screened factors for further optimization. The optimized conditions for this system were 0.7 g/L , 1.19 g/L GL, and cultivation for six days. The biotransformation of GL to MGGA could reach up to 35.72%, which is a good result for this kind of transformation.
 Keywords
Glycyrrhizin;Aspergillus niger;Plackett-Burman Design;Biotransformation;Box-Behnken Design;
 Language
English
 Cited by
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