JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Influence of Zeta Potential on Fractional Precipitation of (+)-Dihydromyricetin
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Korean Chemical Engineering Research
  • Volume 53, Issue 6,  2015, pp.831-835
  • Publisher : The Korean Institute of Chemical Engineers
  • DOI : 10.9713/kcer.2015.53.6.831
 Title & Authors
Influence of Zeta Potential on Fractional Precipitation of (+)-Dihydromyricetin
Ha, Geon-Soo; Kim, Jin-Hyun;
  PDF(new window)
 Abstract
This study evaluated the influence of the zeta potential of silica-alumina on the behavior in terms of purity, yield, and precipitate shape and size of fractional precipitation in the fractional precipitation process for the purification of (+)-dihydromyricetin. The optimal silica-alumina amount (surface area per working volume of reacting solution) for zeta potential control was . As the zeta potential value of silica-alumina increased, (+)-dihydromyricetin yield and precipitate size were increased. The use of silica with the highest value of the zeta potential (+4.99 mV) as a zeta potential-controlling material increased the (+)-dihydromyricetin yield by 2-fold compared with that of the use of alumina with the lowest value of the zeta potential (-19.00 mV). In addition, the (+)-dihydromyricetin yield and precipitate size was inversely correlated with the absolute value of the zeta potential. On the other hand, the purity of (+)-dihydromyricetin had almost no effect on changes in the zeta potential of silica-alumina.
 Keywords
(+)-Dihydromyricetin;Purification;Fractional Precipitation;Silica-Alumina;Zeta Potential;
 Language
Korean
 Cited by
 References
1.
An, S. W., Kim, Y. G., Kim, M. H., Lee, B. I., Lee, S. H., Kwon, H. I., Hwang, B. and Lee, H. Y., "Comparison of Hepatic Detoxification Activity and Reducing Serum Alcohol Concentration of Hovenia dulsis Thunb and Alnus Japonica Steud," Korean J. Medicinal. Crop. Sci., 7, 263-268(1999).

2.
Hase, K. and Basnet, P., "Effect of Hovenia dulcis on Lipopolysaccharide-induced Liver Injury in Chronic Alcohol-fed Rats," J. Trad. Med., 14, 28-33(1997).

3.
Lee, M. K., Kim, Y. G., An, S. W., Kim, M. H., Lee, J. H., Lee, H. Y., "Biological Activities of Hovenia dulcis Thunb," Korean J. Medicinal. Crop. Sci., 7, 185-192(1999).

4.
Sakai, K., Yamane, T., Saitoh, Y., Ikawa, C., Nishihata, T., "Effect of Water Extracts of Crude Drugs in Decreasing Blood Alcohol Concentrations in Rats," Chem. Pharm. Bull., 35, 4597-4604(1987). crossref(new window)

5.
Yoo, S. M., Mun, S. and Kim, J. H., "Recovery and Pre-purification of (+)-Dihydromyricetin from Hovenia dulcis," Process Biochem., 41, 567-570(2006). crossref(new window)

6.
Du, Q., Cai, W., Xia, M. and Ito, Y., "Purification of (+)-Dihydromyricetin from Leaves Extract of Ampelopsis Grossedentata using High-Speed Countercurrent Chromatograph with Scale-up Triple Columns," J. Chromatogr. A., 973, 217-220(2002). crossref(new window)

7.
Yohsikawa, M., Murakami, T., Ueda, T., Yoshizumi, S., Ninomiya, K., Murakami, N., et al. "Bioactive Constituents of Chinese Natural Medicines. III. Absolute Stereostructures of New Dihydroflavonols, Hovenitins I, II, and III, Isolated from Hoveniae Semen Seu Fructus, the Seed and Fruit of Hovenia dulcis Thunb. (Rhamnaceae): Inhibitory Effect on Alcohol-Induced Muscular Relaxation and Hepatoprotective Activity," Yakugaku Zasshi., 117, 108-118 (1997). crossref(new window)

8.
Song, X. and Ren, Q., "Preparation and Application of Dihydromyricetin," CN. Patent No. 1,288,892(2001).

9.
Zhang, Y., "Process for Preparing Dihydromyricetin from Porcelain Ampelopsis," CN. Patent No. 1,393,443(2003).

10.
Lee, K. H. and Kim, J. H., "Development and Optimization of Fractional Precipitation for the Pre-purification of (+)-Dihydromyricetin," Biotechnol. Bioproc. Eng., 13, 274-278(2008). crossref(new window)

11.
Lim, M. K. and Kim, J. H., "Improvement of the Fractional Precipitation Process for the Purification of (+)-Dihydromyricetin," Korean J. Biotechnol. Bioeng., 42, 25-31(2014).

12.
Han, M. G. and Kim, J. H., "Evaluation of a High Surface Area Fractional Precipitation Process for the Purification of Paclitaxel from Taxus chinensis," Biotechnol. Bioproc. Eng., 17, 1018-1024 (2012). crossref(new window)

13.
Ryu, H. K. and Kim, J. H., "Effect of Zeta Potential on Fractional Precipitation for the Purification of Paclitaxel from Plant Cell Cultures of Taxus chinensis," Korean J. Biotechnol. Bioeng., 42, 114-120(2014).

14.
Jeon, Y. L. and Kim, J. H., "Precipitation Characteristics of Paclitaxel in Solvent Systems with Different Ion Exchange Resins," Korean J. Chem. Eng., 30, 1954-1959(2013). crossref(new window)

15.
Gregg, S. J. and Sing, K. S. W., "Adsorption, Surface Area and Porosity," 2nd ed. Academic Press. New York., pp. 41-110(1982).

16.
Cho, E. B., Cho, W. K., Cha, K. H. and Park, J. S., "Enhanced Dissolution of Megestrol Acetate Microcrystals Prepared by Antisolvent Precipitation Process Using Hydrophilic Additives," Int J. Pharm., 396, 91-98(2010). crossref(new window)