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The Effects of Gyejibokryeong-hwan (桂枝茯苓丸) for Wound Healing after Skin Suture
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 Title & Authors
The Effects of Gyejibokryeong-hwan (桂枝茯苓丸) for Wound Healing after Skin Suture
Jung, Hoon; Lee, Eun-Jung; Oh, Min-Seok;
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Objectives There is few Korean medicinal studies about post-operation wound healing despite much effort for minimizing wound or post-op scar. The aim of this study is to evaluate the wound healing effect of Gyejibokryeong-hwan (Guizhifuling-wan, GBH) after skin suture. Methods < In vitro > We observed anti-oxidative and anti-inflammatory effect by using lipopolysaccharide (LPS)-treated RAW 264.7 cells. For anti-oxidation, we mesured the total amount of polyphenol, flavonoid, DPPH scavenging ability, ABTS scavenging ability and the value of ROS production, and for anti-inflammation, we mesured the amount of NO and pro-inflammatory cytokines (, , IL-6). < In vivo > Thirty SD rats were divided into five equal groups (n
Gyejibokryeong-hwan;Guizhifuling-wan;wound healing;suture;
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계지복령환(桂枝茯苓丸)의 배오(配伍)분석과 그 생리활성,김도회;정양삼;윤미정;윤유식;신순식;

대한한의학방제학회지, 2016. vol.24. 4, pp.353-365 crossref(new window)
Torotora GJ, Derrickson BH, Theintegumentary system. In principles of anatomy and physiology. 12th ed. Hoboken. John Wiley & Sons Inc. 2009;147-74.

Matolcsy AG. Keratinization. J invest dermatol. 1976;67(1):20-5. crossref(new window)

Fore J. A review of skin and the effects of aging on skin structure and function. Ostomy wound manage. 2006;52(9):24-35.

Park KH. wound management. Seoul. Gunja publish co. 2010:8-13.

Ayman Atiba, Mayumi Nishimura, Shizuko Kakinuma, Takeshi Hiraoka, Masanobu Goryo, Yoshiya Shimada, Hiroshi Ueno, Yuji Uzuka. Aloe vera oral administration accelerates acute radiation delayed wound healing by stimulating transforming growth factor-and fibroblast growth factor production. The American journal of surgery. 2011;201(6):809-18. crossref(new window)

Song YS. Clinical study of primary closure and delayed primary closure. Chosun university. 1993.

Swanson NA. Atlas of cutaneous surgery. 1st ed. Boston. Little, Brown and Company. 1987:163-9.

Park YY. A study on the purchasing decisions for medical care:Focusing on cosmetic surgery. Kyonggi university. 2004;55-8.

Suh MJ, Lee JH. Tissue response of incised wound healing in sutured sites by staple and various suture materials. Journal of Korean association of maxillofacial plastic and reconstructive surgeons. 1996;18(3):500-14.

Jang JP, Kim KW, Lee JH, Kim CJ. A comparative study of wound healing following partial glossectomy of rat tongue using $CO_2$ laser and scalpel. Journal of the Korean association of oral and maxillofacial surgeons. 2000;26(5):437-45.

Choi CS. The effects of surgery methods and low level laser sealing on the healing of the wound tissue. Busan university. 1989.

2008 Health Technology R&D Development strategy Instruction Manual. Korea helth Industry development Institute. 2008;161-8.

Yuan zhu. original Editor's note Uihak-ipmun 2nd. Namsandang publish co. 1996:391,408,417,426,605-6.

Hur J. Dong-uibogam. Seoul. Bubin publishers co. 1999:1415-7,1425.

Chae BY. Oriental Surgery. Seoul. Gomun publish co. 1987:2.

Bak JW, Sim BY, Kim DH. The effects of Danggwisusan on restoration ability in wound induced animal models. Korean journal of herbology. 2014;29(5):55-63.

Shin GW. The Effects of Jawoongo plus rehmanniae radix on the wound healing of rats. Journal of the Korean surgical society. 1999;12(1):99-112.

Chen CZ. Chinese medicine treatment and prescription. 4th edition. Beijing:People health publish co. 2003:417.

Oriental medical college herbal medicine professors. Herbal medicine. Seoul. Younglim publish co. 2009;409.

Jo HG, Park AR, Kee YB, Kang DH, Choi JB and Sil JU. A clinical trial on the blood stasis and efficacy of Kyejibokryong-whan (Guizhifuling-wan) in the patients with motor vehicle accident. J. oriental rehab Med. 2011;21(3):45-55.

Zhang J. Zhongjing collection. Taipei:Jipmoon publication. 1972;172-3, 228, 236.

Yoshihisa Y, Furuichi M, Ur Rehman M, Ueda C, Makino T, Shimizu T. The traditional Japanese formula Keishibukuryogan inhibits the production of inflammatory cytokines by dermal endothelial cells. Mediators of Inflammation. 2010;2010:804298.

Hiromasa O, Hiroaki O, Kenzo M, Tomonori S, Shuji A. A case report on chronic eczema well treated with decoctions of derivatives of Keishi bukuryo-Gan. Japanese journal of oriental medicine. 1987;37(4):289-95.

Nobuyasu S, Tatsumi H, Yukitaka H, Takao N, Yuji K, Atsushi C, Kenji O, Toshiaki K, Yoshiro H, Katsutoshi T. lmportance of "Question and Answer" about psychoiogical background in cases of chronic urticari sauccessfully treated with Kampo therapy. Japanese journal of oriental medicine. 2007;58(4):723-8.

Kwok DY. Translation with Jinguiyaolue. bundang. Seonbosa. 2002:471.

Lee, S.O., Lee, H.J., Yu, M.H., Im, H.G., Lee, I.S. Total polyphenol contents and antioxidant activities of methanol extracts from vegetables produced in Ullung island. Korean J. food sci. Technol. 2005;37(2):233-240.

Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay - electron-transfer reactions with organic compounds in solutions containing nitrite or nitrate. journal of free radical biology and medicine. 1999;26(9-10):1231-7. crossref(new window)

Laird DF, Mucalo MR, Yokogawa Y. Growth of calcium hydroxyapatite (Ca-HAp) on cholesterol and cholestanol crystals from a simulated body fluid: A possible insight into the pathological calcifications associated with atherosclerosis. J Colloid Interface Sci. 2006;295:348-363. crossref(new window)

Karmen A. A note on the spectrophotometric assay of glutamic-oxalacetic transaminase in human blood serum. J Clin Invest. 1955;34:131-3.

Choi BK, Jung SY, Park GS, Cho JH. Reactive oxygen substances and diseases. Seoul. Sinil publish co. 2004;184-218.

Korean society of plastic and reconstructive surgeons. Plastic surgery=Textbook of plastic surgery Chapter 3. Wound healing. 2009:83-9.

Yang JI. The effect of sildenafil on wound healing in rat. Dong-A university. 2010.

Jang IT, Lee JH, Ji GC, Park YG, Kim SJ. The essentials of surgery 5th. Seoul. Gunja publish co. 2005;144-8.

Jang IS, Im P. Effects of occlusive dressing and antibiotic ointment on the Ischemic ulcer wound healing. The journal of catholic medical college. 1994;47(3):1205-15.

Han CD, Lee WM, Lee HB, Han MH, Yoo HW. Effects of steroid and nonsteroidal anti-inflammatory drugs on acute wound healing and collagen synthesis in rat skin. The journal of the Korean orthopaedic association. 2003:38(4):393-7. crossref(new window)

Min SK, Kim GH, Oh MH. The effects of wound healing of pulsed ultrasound in diabetic Induced rats. Journal of the Korean academy of clinical electrophysiology. 2003;1(1):89-100.

Sau HS. Negative pressure wound therapy on closed surgical incision with dead space: Animal studies in swine. Ulsan universitiy. 2012.

Cho YS. Reconstruction of cutaneous defect after skin surgery by sutureless Burow's graft using adhesive skin tape (Steri-strip). Chonbuk national university. 2011.

Jung SM, Doo JK. A comparative study of tensile strength in vitro and histologic reaction on rabbits between TRISORB suture materials and traditional suture materials (Dexon, Vicryl, Medifit). Obstetrics & gynecology science. 1997;10(40):2217-22.

Kim HJ. The effect of Leukosan Skinlink$^{(R)}$ for laceration repair at emergency department. Keimyung university. 2014.

Cha JH. Combined treatment of Keloids or hypertrophic scars. Ewha medical journal. 1996;19(1):103-7. crossref(new window)

Kim UK, Nam HM, Park SY, Park SD, Park G. The comparative study on the hypertrophic scarring and keloid after surgery of topical silicone gel and topical tretinoin. The journal of Korean Dermalogical association. 2010;48(20):214.

Ging KS. Effects of electroacupuncture stimulation on wound healing in wounded rats. Dongshin university. 2009.

Hong CH. Effect of astragali radix pharmacocupuncture on wound healing of full-thickness skin wounds in mouse. Dongeui university. 2015.

Ahn SH. The Myogenic effect of Sagunjatang and Sagunjatanggami Astragalus membranaceus Extract. Wonkwang university. 1989.

Sin MH, No SS. Kim BT. Myogenic effect of Sibjeondaebotanggamibang. The journal of society of Korean medicine. 1993:14(1):31-44.

Kim SK, Choi HY, Jee SY, Lee SK. An experimental study on the synergic Effect of Jawoongo and gentamicin in dermal wound healing and skin wound Infection against staphylococcus aureus, streptococcus pyogenes, and pseudomonas aeruginosa. Korea journal of herbology. 2004:19(1):137-60.

Kwon SK, Choi MS, Yoon SH, Kim DI. Effect of herbal decoction for sitz bath on dermoepidermal recovery to wound tissue in rats. The journal of oriental gynecology. 2010;23(1):30-41.

Han DO, Kim GH, Choi YB, Shim IS, Lee HJ, Lee YG, Kim JH, Chang GT, Hahm DH. Healing effects of astragali radix extracts on experimental open wounds in rats. Korean journal of oriental physiology & pathology. 2005;19(5):92-7.

Mary R. Marginal to mainstream alternative medicine in America. Cambridge university press. 2004;43.

Oriental medical college herbal botany professors. Herbal botany. Seoul. Younglim publish co. 1991;124-5, 193-5, 302-4, 423-4, 581-3.

Cho JH. A pilot study of the difference between Gyejibongnyeong- hwan and Gyejibongnyeong-hwan combined acupuncture therapy on the primary dysmenorrhea. The J. of oriental obstetrics & gynecology. 2007;20(1):161-8.

Xie SP, Feng YM. On the discussion on Geijibokryunghwan article. Henan traditional Chinese medicine. 1994;14(2):73-4.

Gao S. Geijibokryunghwan treated prostatic hypertrophy. Zhejiang journal of traditional Chinese medicine. 1983;11:493.

Iijima K, Tanaka M, Toriizuka K, Cyong JC. Effects of kampo medicines on the clearance of circulating immune complexes in mice. Journal of ethanopharmacology. 1994;41:77-83. crossref(new window)

Ha DJ, Jeong KJ and Lee KN. Effect of Geijibokryung-hwan on analgesic, anti-inflammation, anti-convulsion, muscle relaxation and changes of body temperature through experimental animal. J. Korean oriental Med. 1995;16(1):339-50.

Park WH, Joo ST, Park KK, Chang YC, Kim CH. Effects of the Geijibokryung-hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HeG2 and Hep3B. Immunopharmacol. Immunotoxicol. 2004;26(1):103-12. crossref(new window)

Yi IH, Lee KS and Song BK. Effect of Geijibokryunghwan aqua-acupuncture on the intravascular coagulation induced by endotoxin in rats. The J. of Oriental Gynecology. 2000;13(1):1-17.

Choi MH. Park WH. Effect of the Geijibokryung-hwan water extracts on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils. Korean J. Oriental Physiol. Pathol. 2006;20(2):477-81.

Kim BJ, Kim YK, Park WH, Ko JH, Lee YC and Kim CH. A water-extract of the Korean traditional formulation Geijibokryung-hwan reduces atherosclerosis and hypercholesterolemia in cholesterol-fed rabbits. Int. Immunopharmacol. 2003;3(5):723-34. crossref(new window)

Song W, Kim DW, Yoon TJ, Kim SH. Study on antitumor activity, antimetastatic effects Geijibokryunghwan. Korean J. oriental physiology & pathology. 2001;15(1):36-41.

Lee SK, Kim HG, Ahan JC, Chung TW, Moon JY, Park SD, Kim JK, Choi DY, Kim CH and Park WH. Effect of the Geijibokryunghwan on human hepatocarcinoma cells. Korean J. oriental physiology & pathology. 2003;17(2):568-73.

Hwang DS, Cho JH, Jang JB and Lee KS. Inhibitory effects of Gaejibokryunghwan on cell proliferation in HeLa cells. J. Korean oriental Med. 2006;27(1):23-35.

Sheng FY, Ohta A, Yamaguchi M. Inhibition of collgen production by traditional Chinese herbal medicine in scleroderma fibroblast cultures. Internal medicine. 1994;33(8):466-71. crossref(new window)

Youm JH, Oh GJ, Yoo YC. Role of nitic oxide in the nickel and cobalt Induced cytotoxicity in RAW 264.7 cell. Annals of occupational and environmental medicine. 2001;13(3):274-7.

Matsukawa A, Ohkawara S, Maeda T, Takagi K, Yoshinaga M. Production of IL-1 and IL-1 receptor antagonist and the pathological significance in lipolysisaccharide- induced arthritis in rabbits. Clin Exp Immunol. 1993;93(2):206-11.

Kim MJ, Park EJ. Feature analysis of different in vitro antioxidant capacity assays and their application to fruit and vegetable samples. J Korean Soc food sci Nutr. 2011;40(7):1053-62. crossref(new window)

Lee SO, Lee HJ, Yu MH, Im HG, Lee IS. Total polyphenol contents and antioxidant activities of methanol extracts from vegetables produced in Ullung island. J Korean soc food Sci Technol. 2005;37(2):233-40.

Ku KM, Kim HS, Kim BS, Kang YH. Antioxidant activities and antioxidant constituents of pepper leaves from various cultivars and correlation between antioxidant activities and antioxidant constituents. J. Appl. Biol. Chem. 2009;52(2):70-6. crossref(new window)

Cho SH, Choi YJ, Rho CW, Choi CY, Kim DS, Cho SH, Reactive oxygen species and cytotoxicity of bamboo (Phyllostachys pubescens) sap. Korean J. foos Preserv. 2008;15(1):105-10.

Ji SJ. Protective effect of Betula platyphylla var. japonica extract against cellular damage induced by reactive oxygen species. Kyunghee university. 2009.

Jang TO, Yoo YH, Hwang YC, Kim HK, Woo HC. Total polyphenol content and antioxidative activities of mistletoe (Viscum album) extracts by supercritical carbon dioxide. J Korean Soc food Sci Nutr. 2010; 39(1):20-4. crossref(new window)

Ahn SI, Heuing BJ, Son JY. Antioxidative activity and nitrite scavenging abilities of some phenolic compounds. Korean J. food cookery Sci. 2007;23:19-24.

Moncada S, Palmer RMJ, Higgs EA. Nitric Oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991;43:109-42.

Wink DA, Mitchell JB. Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide. Free radic biol Med. 1998;25(4-5):434-56. crossref(new window)

Byun HS. Effects of chitosan on skin wound healing in pigs and monkeys. Chungnam national university. The journal of Korean society of veterinary clinics. 2013;30(4):241-6.

Kim YD, Hwang HB, Park MH, Moon JI. Glaucoma filtering surgery with low concentration of cyclosporin a in rabbits: A pilot study. Journal of the Korean ophthalmological society. 2010;51(5):740-5. crossref(new window)

Chung KF, Barnes PJ. Cytokines in asthma. Thorax. 1999;54(9):825-57. crossref(new window)

Mori L. et al. Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1(TNFR1)-IgG1-treated and TNFR1-deficient mice. J Immunol. 1996;157:3178-82.

Cho D, Kang KH, Chang MW. Concentration of IL-$1{\beta}$, IL-6, IL-8, and TNF-${\alpha}$ in cerebrospinal fluid of patients with meningitis and control. Korean journal of immunology. 1999;21(2):99-107.

Jeon SY, Lee JH, Min KH, Hong SH, Lee WM, Chae JD, Jeon JH. Comparison of antibacterial ointments for antibacterial and wound healing effect on Infected full thickness skin defect in the mouse. Journal of the Korean society of plastic and reconstructive surgeons. 2010;37(2):115-21.

Argamaso RV, Wiseman GM, The use of combined hyperbaric oxygen and polymyxin B in the treatment of pseudomonas infections of mice. Plast Reconstr Surg. 1967;40(1):81-5. crossref(new window)

Dufour DR, Lott JA, Frederick S. Nolte, David R. Gretch, Raymond S. Koff, Leonard B. Seeff. Diagnosis and monitoring of hepatic Injury. II. Recommendations for use of laboratory tests in screening, diagnosis, and monitoring. clinical chemistry. 2000;46(12):2050-68.

Pratt Ds, Kaplan MM. Evaluation of abnormal liver enzyme results in asymptomatic patients. N Engl J Med. 2000;342:1266-71. crossref(new window)

Seoul national university college of medicine. Kidney and urinary tract. Seoul. Seoul national university publish co. 2005:159.

Cho HI. Renal function tests. Diagnosis and treatment. 1986;6(4):445-7.

Herberston BM, Lee YM, Cho HG, et al. Alveolar type2 cell abnormalities and peroxide formation in lungs of rats given IL-1 intratracheally. Inflammation. 2000;24(4):289-303. crossref(new window)

Hamblin AS. Cytokines and cytokine receptors. 2nd edition. New York:Oxford university press; 1993:21-43.

Standiford TJ, Strieter RM, Chensue SW, Westwick J, Kasahara K, Kunkel SL. IL-4 inhibits the expression of IL-8 from stimulated human monocytes. J Immunol. 1990;145:1435.

Mauch C, Krieg T, Bauer EA. Role of the extracellular matrix in the degradation of connective tissue. Arch dermatol Res. 1994;287:107-14. crossref(new window)

Shaida A, Kenyon G, Devalia J, Davies RJ, MacDonald TT, Pender SL. Matrix metalloproteinases and their inhibitors in the nasal mucosa of patients with perennial allergic rhinitis. J Allergy clin immunol 2001;108(5):791-6. crossref(new window)

Harding KG, Morris HL, Patel GK. Science, medicine and the future:gealing chronic wounds. BMJ. 2002;324:160-3. crossref(new window)

Hoshino M, Nakamura Y, Sim J, Shimojo J, Isogai S. Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation. J allergy clin immunol. 1998;102(5):783-8. crossref(new window)

Lee SH. Effect of fucoidan on the expression of matrix metalloproteinase-1 and type I procollagen. Kosin university. 2008.

Kristina A, Szaboa, Richard J, Ablinb, Gurmit GS. Matrix metalloproteinases and the immune response. Clin Appl immunol reviews. 2004;4:295-319. crossref(new window)

Mott JD, Werb Z. Regulation of matrix biology by matrix metalloproteinases. Curr opin cell biol. 2004;16:558-64. crossref(new window)

Palosaari H, Pennington CJ, Larmas M, Edwards DR, Tjaderhane L, Salo T. Expression profile of matrix metalloproteinases( MMPs) and tissue inhibitors of MMPs in mature human odontoblasts and pulp tissue. Eur J oral Sci. 2003;111:117-27. crossref(new window)

Cook H, Davies KJ, Harding KG, Thomas DW. Defective extracellular matrix reorganization by chronic wound fibroblasts is associated with alterations in TIMP-1, TIMP-2, and MMP-2 activity. J invest dermatol. 2000;115(2):225-33. crossref(new window)

Zucker S, Pei D, Cao J, Lopez-Otin C. Membrane type-matrix metalloproteinases(MT-MMP). Curr top Dev Biol. 2003;54:1-74. crossref(new window)