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Wound Healing Effect of Low Molecular PDRN on Experimental Surgical Excision Rat Model
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 Title & Authors
Wound Healing Effect of Low Molecular PDRN on Experimental Surgical Excision Rat Model
Yun, Jong-Kuk; Yoon, Hye-Eun; Park, Jeong-Kyu; Kim, Mi Ryeo; Kim, Dae-Ik;
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This study was performed to investigate the wound healing effect of skin regeneration cosmetics utilizing low molecular weight Polydeoxynucleotide (PDRN). High purity PDRN was prepared from salmon testes poly-deoxy-ribonucleotide through protein and toxin removal process and molecular weight reduction. In order to evaluate the wound healing effect of PDRN in SD rats, 4 sites of dorsal skin of each animal were excised by using biopsy punch and of test solution was topically applied once daily for 4 weeks. The tissue changes were observed for every week during the application periods. After applying the PDRN to the wound, the skin was cut flower and contraction of the wounds more quickly, and the coating of PDRN in the wound area was reduced significantly as compared to the positive control group applied. The microscopic observation of stained tissue showed that a positive control was most rapid in re-epithelialization ability followed by the PH group, PDRN group, HA group. In addition, transforming growth factor () and vascular endothelial growth factor (VEGF), such as in the growth factor was similar to the results of staining of tissue lesions. In conclusion, it is determined that the low molecular weight PDRN has the therapeutic effect to the wound, and could be used as a functional material of cosmetics and medical industries.
PDRN (polydeoxyribonucleotide);cosmeceuticals;anti-inflammation;wound healing;wound repair;
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