Advanced SearchSearch Tips
A Study of Skin Biophysical Parameters and Biomarkers related to the Anatomical Site and Age in Korean Women
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
A Study of Skin Biophysical Parameters and Biomarkers related to the Anatomical Site and Age in Korean Women
Cho, Seok-Cheol; Nam, Gaewon;
  PDF(new window)
The skin is one of the largest organs in our body and participates in many of the human organism`s physiological and pathological events. Skin function were known for self-maintenance and self-repair, mechanical and chemical stress protection, protection against UV and environmental pathogenic micro-organisms, production of vitamin D, and social and psychological function through the physical aspect. The aim of this study was to evaluate the variation of biophysical parameters and to find relation with skin biomarkers in different anatomical site and age in Korean women. About 70 healthy volunteers in age range 20 to 49 were participated in this test. Test areas were the forearms and the cheek. Investigation to determine biophysical parameters on human skin, was carried out using various non-invasive methods. For analysis to skin biomarkers, we studied to examine various biomarkers for the quantitative determination of cortisol, fibronectin, keratin-1, 10, and 11, involucrin, and keratin-6 in human face and forearm. And we measured to skin biophysical parameters for skin anatomical site and age difference with non-invasive methods. As results of measuring site, some parameters were have following significant difference, stratum corneum hydration, trans epidermal water loss and skin color (L and a value). As results of age difference, skin colors were had only significant difference with age. For cortisol, keratin-6, fibronectin, keratin-1, 10, 11 contents, there were no significant difference in age and site. However, involucrin level in the cheeks were the highest for age group 30 ~ 39 compared to other age groups. These results suggest that in individual skin condition may explain detailed skin state variation.
Non-invasive measurement;biomarker;age and anatomical site;
 Cited by
J. Uitto, Understanding premature skin aging, N. Engl. J. Med., 337(20), 1463 (1997). crossref(new window)

C. R. Lovell, K. A. Smolenski, V. C. Duance, N. D. Light, S. Young, and M. Dyson, Type I and III collagen content and fibre distribution in normal human skin during ageing, Br. J. Dermatol., 117(4), 419 (1987). crossref(new window)

N. A. Fenske and C. W. Lober, Structural and functional changes of normal aging skin, J. Am. Acad. Dermatol., 15(4 Pt 1), 571 (1986). crossref(new window)

G. Roupe, Skin of the aging human being, Lakartidningen, 98(10), 1091 (2001).

R. M. Lavker, Structural alterations in exposed and unexposed aged skin, J. Invest. Dermatol., 73(1), 59 (1979). crossref(new window)

L. Baumann, Skin ageing and its treatment, J. Pathol., 211(2), 241 (2007). crossref(new window)

M. El-Domyati, S. Attia, F. Saleh, D. Brown, D. E. Birk, F. Gasparro, H. Ahmad, and J. Uitto, Intrinsic aging vs photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin, Exp. Dermatol., 11(5), 398 (2002). crossref(new window)

A. Oikarinen, The aging of skin: chronoaging versus photoaging, Photodermatol. Photoimmunol. Photomed., 7(1), 3 (1990).

S. Shuster, M. M. Black, and E. McVitie, The influence of age and sex on skin thickness, skin collagen and density, Br. J. Dermatol., 93(6), 639 (1975). crossref(new window)

C. E. Griffiths, A. N. Russman, G. Majmudar, R. S. Singer, T. A. Hamilton, and J. J. Voorhees, Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid), N. Engl. J. Med., 329(8), 530 (1993). crossref(new window)

G. J. Fisher, S. Kang, J. Varani, Z. Bata-Csorgo, Y. Wan, S. Datta, and J. J. Voorhees, Mechanisms of photoaging and chronological skin aging, Arch. Dermatol., 138(11), 1462 (2002).

D. Black, A. D. Pozo, J. M. Lagarde, and Y. Gall, Seasonal variability in the biophysical properties of stratum corneum from different anatomical sites, Skin Res. Technol., 6(2), 70 (2000). crossref(new window)

E. Berardesca, EEMCO guidance for the assessment of stratum corenum hydration: electrical methods, Skin Res. Technol., 3(2), 126 (1997). crossref(new window)

J. L. Parra and M. Paye, EEMCO guidance for the in vivo assessment of skin surface pH, Skin Pharmacol. Appl. Skin Physiol., 16(3), 188 (2003). crossref(new window)

G. E. Pierard, EEMCO guidance for the assessment of skin colour, J. Eur. Acad. Dermatol. Venereol., 10(1), 1 (1998).

A. Pierre, Measuring the skin, Berlin, Springer, 173 (2004).

V. Terskikh, Y. A. Vorotelyak, and A. Vasiliev, Self-renewal of stem cells, Acta. naturae, 1(2), 61 (2009).

T. Mauricio, Y. Karmon, and A. Khaiat, A randomized and placebo-controlled study to compare the skin-lightening efficacy and safety of lignin peroxidase cream vs 2% hydroquinone cream, J. Cosmet. Dermatol., 10(4), 253 (2011). crossref(new window)

H. Qiu, X. Long, J. C. Ye, J. J. Senee, A. Laurent, R. Bazin, F. Flament, A. Adam, J. Coutet, and B. Piot, Influence of season on some skin properties: winter vs summer, as experienced by 354 Shanghaiese women of various ages, Int. J. Cosmet. Sci., 33(4), 377 (2011). crossref(new window)

Y. Ogura, T. Kuwahara, M. Akiyama, S. Tajima, K. Hattori, K. Okamoto, S. Okawa, Y. Yamada, H. Tagami, M. Takahashi, and T. Hirao, Dermal carbonyl modification is related to the yellowish color change of photo-aged Japanese facial skin, J. Dermatol. Sci., 64(1), 45 (2011). crossref(new window)

M. Simon and H. Green, Involucrin in the epidermal cells of subprimates, J. Invest. Dermatol., 92(5), 721 (1989). crossref(new window)