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A Study of Stabilization for Insoluble Active Ingredients Using Swollen Micelles
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 Title & Authors
A Study of Stabilization for Insoluble Active Ingredients Using Swollen Micelles
Kim, Su Ji; Jeong, You Lee; Nam, Jin Ju; Jang, Ji Hui; Yeo, Hye Lim; Yoon, Moung Seok; Yoo, Kweon Jong; Lee, Jun Bae;
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Micelles, which are called solubilization formulation, have been widely used in skin lotion, mist or various formulations for the purpose of solubilizing the fragrance rather than the role of the active ingredient carrier because the particles are very small. In this study, we developed the swollen micelle having a transparent appearance to deliver -sitosterol. When preparing the swollen micelle, solubility parameter was considered with active ingredient. This method allowed insoluble active ingredient to be safely entrapped inside the micelles. Stability of micelle was evaluated by dynamic light scattering (DLS). The transparency and shape of the micelles were confirmed by cryo-TEM. In addition, through the thermal analysis using DSC, -sitosterol was found to be stably present in the swollen micelles. These results indicate that swollen micelles considered solubility parameter could be used as a new carrier for the insoluble active ingredients.
solubilization;solubility parameter;swollen micelle;-sitosterol;
 Cited by
M. B. Mathews and E. Hirschhorn, Solubilization and micelle formation in a hydrocarbon medium, J. Colloid Sci., 8(1), 86 (1953). crossref(new window)

R. L. Price, Exploring structure and dynamics of biological assemblies by digital-imaging cryo-TEM, Microsc. Microanal., 11, 1082 (2005).

S. Sharma and K. Sarangdevot, Nanoemulsions for cosmetics, IJARPB, 2(3), 408 (2012).

M. S. Lim, M. A. Park, and S. N. Park, Preparation of nano-emulsion containing Polygonum aviculare extract for enhanced transdermal delivery, Appl. Chem. Eng., 23(2), 222 (2012).

C. O. Rangel-Yagui, A. Pessoa-Jr, and L. C. Tavares, Micellar solubilization of drugs, J. Pharm. Pharmaceut. Sci., 8(2), 147 (2005).

P. H. Elworthy, A. T. Florence, and C. B. Macfarlane, Solubilization by surface-active agents and its applications in chemistry and the biological sciences, Solubilization by surface-Active Agents, Chapman & Hall, London (1968).

S. Loizou, I. Lekakis, G. P. Chrousos, and P. Moutsatsou, Beta-sitosterol exhibits anti-inflammatory activity in human aortic endothelial cells, Mol. Nutr. Food. Res., 54(4), 551 (2010). crossref(new window)

M. B. Gupta, R. Nath, N. Srivastava, K. Shanker, K. Kishor, and K. P. Bhargava, Anti-inflammatory and antipyretic activities of ${\beta}$-sitosterol, Planta Med., 39(6), 157 (1980). crossref(new window)

J. T. Fried, Polymer science and technology, Englewood cliffs, New Jersey: Prentice Hall PTR, 99 (1995).

S. H. Pine and J. B. Hendrickson, Organic chemistry 4th Ed, McGraw-Hill Book company, 830 (1980).