Advanced SearchSearch Tips
The Effect of Jeju Wild Ginseng Extracts on Skin Barrier via Serine-Palmitoyltransferase
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
The Effect of Jeju Wild Ginseng Extracts on Skin Barrier via Serine-Palmitoyltransferase
Kim, Hyo Min; Lee, Jung No; Kim, Jae Moon; Kim, Sung Kyu; Park, Sung-Min;
  PDF(new window)
Skin is the largest organ that protects the body from the external environmental factors such as smog, cigarette smoke, UV. Protective skin barrier is composed with keratinizational keratinocytes and intercellular lipids such as ceramides, cholesterols and fatty acids combined by the lamellar liquid crystal structure. In this research, we confirmed that the Jeju wild ginseng (JWG) extracts dose-dependently increased the expression of serine-palmitoyltransferase (SPT) protein which is associated with ceramide biosynthesis. In addition, emulsion containing 5% JWG extract was applied on skin of human volunteers for 2 weeks and then significantly reduced transepidermal water loss (TEWL) compared to that of control group. As a results, JWG extract increased the biosynthesis of ceramides that is the key components of the skin lipid through enhancing expression of SPT. In addition, JWG extract reduced TEWL resulting in improvement of skin barrier function. In this context, we suggest that JWG extract could be used as a skin barrier enhancer and moisturing agents in cosmetic fileds.
Jeju wild ginseng (JWG);ceramide;SPT;TEWL;skin barrier;
 Cited by
K. R. Feingold and P. M. Elias, Role of lipid in the formation and maintenance of the cutaneous permeability barrier, Biochim. Byophys. Acta, 1841(3), 280 (2003).

A. D. Nardo, P. Wertz, A. Giannetti, and S. Seidenari, Ceramide and cholesterol composition of the skin of patients with atopic dermatitis, Acta Derm. Venereol., 78, 27 (1998). crossref(new window)

G. Imokawa, S. Akasaki, Y. Minematsu, and M. Kawai, Impotance of intercellular lipids in water-retention properties of the stratum corneum: induction and recovery study of surfactant dry skin, Arch. Dermatol. Res., 281(1), 45 (1989). crossref(new window)

J. L. Sugaman, The epidermal barrier in atopic dermatitis, Semin. Cutan. Med. Surg., 27(2), 108 (2008). crossref(new window)

K. Nakajima, M. Terao, M. Takaishi, S. Kataoka, N. Goto-Inoue, M. Setou, K. Horie, F. Sakamoto, M. Ito, H. Azukizawa, S. Kitaba, H. Murota, S. Itami, I. Katayama, K. Takeda, and S. Sano, Barrier abnormality due to ceramide deficiency leads to psoriasiform inflammation in a mouse model, J. Invest. Dermatol., 133(11), 2555 (2013). crossref(new window)

Y. Shirakura, K. Kikuchi, K. Matsumura, K. Mukai, S. Mitsutake, and Y. Igarashi, 4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin, Lipids Health Dis., 11(1), 108 (2012). crossref(new window)

E. Hashizume, T. Nakano, A. Kamimura, and K. Morishita, Topical effects of N-acetyl-L-hydroxyproline on ceramide synthesis and alleviation of pruritus, Clin. Cosmet. Investig. Dermatol., 6, 43 (2013).

K. K. Hong, H. R. Cho, W. C. Ju, Y. Cho, and N. I. Kim, A study on altered expression of serine palmitoyltransferase and ceramidase in psoriatic skin lesion, J. Korean Med. Sci., 22(5), 862 (2007). crossref(new window)

W. M. Holleran, K. R. Feingold, M. Q. Man, W. N. Gao, J. M. Lee, and P. M. Elias, Regulation of epidermal sphingolipid synthesis by permeability barrier function, J. Lipid Res., 32(7), 1151 (1991).

P. W. Wertz, D. T. Downing, R. K. Freinkel, and T. N. Traczyk, Sphingolipids of the stratum corneum and lamellar granules of fetal rat epidermis, J. Invest. Dermatol., 83(3), 193 (1984). crossref(new window)

W. M. Holleran, M. Mao-Qiang, W. N. Gao, G. K. Menon, P. M. Elias, and K. R. Feingold, Sphingolipids are required for mammalian barrier function: inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation, J. Clin. Invest., 88(4), 1338 (1991). crossref(new window)

S. Stachowitz, F. Alessandrini, D. Abeck, J. Ring, and H. Behrendt, Permeability barrier disruption increases the level of werine palmitoyltransferase in human epidermis, J. Invest. Dermatol., 119(5), 1048 (2002). crossref(new window)

S. A. Anoja, J. A. Wu, and C. S. Yuan, Ginseng phamacology: multiple constituents and multiple actions, Biochem. Pharmacol., 58(11), 1685 (1999). crossref(new window)

M. S. Blois, Antioxidant determinations by the use of a stable free radical, Nature, 181, 1199 (1958). crossref(new window)

K. Hanada, Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism, Biochim. Byophys. Acta, 1632(1), 16 (2003). crossref(new window)

H. Farwanah, K. Raith, R. H. H. Neubert, and J. Wohlrab, Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin, Arch. Dermatol. Res., 296(11), 514 (2005). crossref(new window)

M. A. Lee and J. H. Ham, Stratum corneum ceramides and free amino acids in the lesion of scaly hand eczema, Kor. J. Dermatol., 38(7), 893 (2000).