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The Effect of Jeju Wild Ginseng Extracts on Skin Barrier via Serine-Palmitoyltransferase
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 Title & Authors
The Effect of Jeju Wild Ginseng Extracts on Skin Barrier via Serine-Palmitoyltransferase
Kim, Hyo Min; Lee, Jung No; Kim, Jae Moon; Kim, Sung Kyu; Park, Sung-Min;
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 Abstract
Skin is the largest organ that protects the body from the external environmental factors such as smog, cigarette smoke, UV. Protective skin barrier is composed with keratinizational keratinocytes and intercellular lipids such as ceramides, cholesterols and fatty acids combined by the lamellar liquid crystal structure. In this research, we confirmed that the Jeju wild ginseng (JWG) extracts dose-dependently increased the expression of serine-palmitoyltransferase (SPT) protein which is associated with ceramide biosynthesis. In addition, emulsion containing 5% JWG extract was applied on skin of human volunteers for 2 weeks and then significantly reduced transepidermal water loss (TEWL) compared to that of control group. As a results, JWG extract increased the biosynthesis of ceramides that is the key components of the skin lipid through enhancing expression of SPT. In addition, JWG extract reduced TEWL resulting in improvement of skin barrier function. In this context, we suggest that JWG extract could be used as a skin barrier enhancer and moisturing agents in cosmetic fileds.
 Keywords
Jeju wild ginseng (JWG);ceramide;SPT;TEWL;skin barrier;
 Language
Korean
 Cited by
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