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Preliminary Evidence for a Metallothionein-like Cd-binding Protein in the Kidney of the Antarctic Clam Laternula elliptica
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  • Journal title : Ocean and Polar Research
  • Volume 23, Issue 4,  2001, pp.337-345
  • Publisher : Korea Institute of Ocean Science & Technology
  • DOI :
 Title & Authors
Preliminary Evidence for a Metallothionein-like Cd-binding Protein in the Kidney of the Antarctic Clam Laternula elliptica
Choi, Hee-Seon, J.; Ahn In-Young; Ryu Soo-Kyung; Lee, Yong-Seok; Lee, In-Sook; Jeong, Kye-Heon;
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 Abstract
A Cd-binding protein was identified in the renal cytosol of the Antarctic clam Laternula elliptica which naturally contains high concentrations of Cd. The Cd-binding protein showed similar characteristics of metallothionein (MT) in molecular weight (about 10-12 kDa) and low spectral absorbance at 280 nm with relatively high absorbance at 254nm. Results of immuno-histochemical staining suggested that the MT-like Cd-binding protein was mainly located in the epithelial cells of the kidney. The MT-like protein was a major ligand of cytosolic Cd as shown in the elution profiles of chromatography and may play an important role in Cd sequestration and accumulation in L. elliptica kidney. A considerable amount of Cd was also found to be associated with particulate fraction, indicating the sequestration to particulate fraction is as important as binding to the cytosolic MT-like protein in Cd accumulation in the kidney.
 Keywords
Laternula elliptica;cadmium;metallothionein-like protein;kidney;Antarctic clam;
 Language
English
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