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Antioxidant Activity of Flavonoids Isolated from Vitex rotundifolia
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  • Journal title : Ocean and Polar Research
  • Volume 33, Issue 3,  2011, pp.255-263
  • Publisher : Korea Institute of Ocean Science & Technology
  • DOI : 10.4217/OPR.2011.33.3.255
 Title & Authors
Antioxidant Activity of Flavonoids Isolated from Vitex rotundifolia
Kim, You-Ah; Lee, Jung-Im; Hong, Joo-Wan; Jung, Myoung-Eun; Seo, Young-Wan;
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The aim of this investigation was to evaluate antioxidant activity of crude extracts from the halophyte Vitex rotundifolia, their solvent fractions, and isolated compounds (1-3). Antioxidant capacity was determined by measuring DPPH radical, and authentic and generated from 3- morpholinsydnonimine (SIN-1) in vitro as well as degree of occurrence of intracellular ROS, NO and GSH in mouse macrophage Raw 264.7 cells. From comparative analysis, MeOH extract, n-BuOH, and 85% aq. MeOH solvent fractions showed significant antioxidant effect in DPPH radical and assay systems. Activity-guided purification of n-BuOH and 85% aq. MeOH fractions led to the isolation of flavonoids 1-3. Among them, compound 1 exhibited excellent antioxidant effect in all bioassay systems tested. On the other hand, compounds 2 and 3 revealed potent inhibitory effect against generated from SIN-1, comparable with the positive control penicillamine.
Vitex rotundifolia;luteolin;vitexicarpin;artemetin;antioxidant activity;
 Cited by
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대한화학회지, 2014. vol.58. 6, pp.686-690 crossref(new window)
Isolation of a New Labdane-type Diterpene from Vitex rotundifolia, Bulletin of the Korean Chemical Society, 2013, 34, 12, 3840  crossref(new windwow)
Chemical Constituents of the Halophyte Vitex rotundifolia, Journal of the Korean Chemical Society, 2014, 58, 6, 686  crossref(new windwow)
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