Advanced SearchSearch Tips
Isolation and Antioxidant Activity of Methyl Aconitates from Arctic Red Alga Polysiphonia stricta
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Ocean and Polar Research
  • Volume 36, Issue 3,  2014, pp.247-254
  • Publisher : Korea Institute of Ocean Science & Technology
  • DOI : 10.4217/OPR.2014.36.3.247
 Title & Authors
Isolation and Antioxidant Activity of Methyl Aconitates from Arctic Red Alga Polysiphonia stricta
Lee, Jung Im; Kong, Chang-Suk; Baek, Seung Oh; Seo, Youngwan;
  PDF(new window)
In our continuing study on the antioxidant activity of Polysiphonia stricta, its crude extract was fractionated into n-hexane, 85% aqueous methanol (85% aq.MeOH), n-butanol (n-BuOH), and water fractions according to solvent polarity. The solvent fractions were evaluated for their potential to inhibit lipid peroxidation and reactive oxygen species (ROS) production in HT 1080 cells. The n-BuOH fraction most strongly inhibited both lipid peroxidation and ROS production in HT 1080 cells. The n-BuOH fraction was further separated by repeated silica gel column chromatography and RP-HPLC to give methyl aconitates (2 and 3). The chemical structure of isolated compounds was determinated by NMR spectral analysis.
Polysiphonia stricta;methyl aconitate;antioxidant activity;
 Cited by
북극식물 Ranunculus hyperboreus의 추출물과 용매분획물의 항산화 활성,이정임;김호준;서효원;공창숙;서영완;

Ocean and Polar Research, 2016. vol.38. 3, pp.185-193 crossref(new window)
Antioxidant Capacity of Crude Extract and Its Solvent Fractions of Arctic Terrestrial Plant Ranunculus heperporeus, Ocean and Polar Research, 2016, 38, 3, 185  crossref(new windwow)
Chai Y, Niu L, Sun XL, Ding JH, Hu G (2006) Iptakalim protects PC12 cells against $H_2O_2$-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel. Biochem Biophys Res Commun 350:307-314 crossref(new window)

Diplock AT, Charleus JL, Crozier-willi G, Kok FJ, Rice-Evans C, Roberfroid M, Stahl W, Vina-Ribes J (1998) Functional food science and defence against reactive oxidative species. Brit J Nutr 80:S77-S112 crossref(new window)

Halliwell B (1996) Antioxidants in human health anddisease. Annu Rev Nutr 16:33-50 crossref(new window)

Hansen MB, Nielsen SE, Berg K (1989) Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 119:203-221 crossref(new window)

Heath RL, Packer L (1968) Photoperoxidation in isolated chloroplasts. I Kinetics and stoichiometry of fatty acid peroxidation. Arch Biochem Biophys 125:189-198 crossref(new window)

Ichiniose M (2003) Inflammatory mechanisms in bronchial asthma and COPD. Tohuku J Exper Med 200:1-6 crossref(new window)

Kooy NW, Royall JA, Ischiropoulos H, Beckman JS (1994) Peroxynitrite-mediated oxidation of dihydrorhodamine 123. Free Radic Biol Med 16:149-156 crossref(new window)

Misra S, Sanyal T, Sarkar D, Bhattacharya PK, Ghosh DK (1989) Evaluation of antileishmanial activity of transaconitic acid. Biochem Med Metab Biol 42:171-178 crossref(new window)

Okimoto Y, Watanabe A, Niki E, Yamashita T, Noguchi N (2000) A novel fluorescent probe diphenyl-1-pyrenylphosphine to follow lipid peroxidation in cell membranes. FEBS Lett 474:137-140 crossref(new window)

Regoli F, Nigro M, Bompadre S, Winston G (2000) Total oxidant scavenging capacity (TOSC) of microsomal and cytosolic fractions from Antarctic, Arctic and Mediterranean scallops: differentiation between three potent oxidants. Aquat Toxicol 49:13-25 crossref(new window)

Rémus-Borel W, Menzies JG, Belanger RR (2009) Aconitate and methyl aconitate are modulated by silicon in powdery mildew-infected wheat plants. J Plant Physiol 166:1413-1422 crossref(new window)

Rémus-Borel W, Shallow N, McNally DJ, Labbe C, Belanger RR (2006) High-speed counter-current chromatography for the study of defense metabolites in wheat Characterization of 5,6-O-methyl trans-aconitic acid. J Chromatogr A 1121:200-208 crossref(new window)

Seo Y, Lee HJ, Kim YA, Lee JI, Kim JH, Chung H, Kang SH (2007) In vitro peroxynitrite scavenging activity of arctic seaweed extracts. Ocean and Polar Res 29:187-191 crossref(new window)

Silva ALP, Holmstrup M, Amorim MJB (2013) Worms from the Arctic are better adapted to freezing and high salinity than worms from temperate regions: Oxidative stress responses in Enchytraeus albidus. Comp Biochem Phys A 166:582-589 crossref(new window)

Xu X, Piggott AM, Yin L, Capon RJ, Song F (2012) Symphyocladins A-G: Bromophenol adducts from a Chinese marine red alga, Symphyocladia latiuscula. Tetrahedron Lett 53:2103-2106 crossref(new window)

Yanishlieva NV, Marinova E, Pokorny J (2006) Natural antioxidants from herbs and spices. Eur J Lipid Sci Technol 108:776-793 crossref(new window)

Zia-ur-Rehman (2006) Citrus peel extract - a natural source of antioxidant. Food Chem 99:450-454 crossref(new window)