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Anticancer Activity of Sulfated Polysaccharides Isolated from the Antarctic Red Seaweed Iridaea cordata
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  • Journal title : Ocean and Polar Research
  • Volume 38, Issue 2,  2016, pp.129-137
  • Publisher : Korea Institute of Ocean Science & Technology
  • DOI : 10.4217/OPR.2016.38.2.129
 Title & Authors
Anticancer Activity of Sulfated Polysaccharides Isolated from the Antarctic Red Seaweed Iridaea cordata
Kim, Hak Jun; Kim, Woo Jung; Koo, Bon-Won; Kim, Dong-Woo; Lee, Jun Hyuck; Nugroho, Wahyu Sri Kunto;
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 Abstract
This study aimed to isolate and characterize sulfated polysaccharides (SPs) from Iridaea cordata and evaluate their anticancer activity. SPs of the Antarctic red seaweed were obtained by (SP1) and ethanol precipitations (SP2) following diluted acid extraction at room temperature. Yields of SP1 and SP2 were approximately 14% and 23%, respectively, of the dry weight of red seaweed. The average molecular mass of the SP1 and SP2 was estimated about and , respectively, by size-fractionation High-Performance Liquid Chromatography (HPLC). From the High-Performance Anion-Exchange Chromatography-Pulsed Amperometric Detection (HPAEC-PAD) analysis, the main monosaccharide was galactose with glucose and fucose as minor components. The sulfate content of SP2 (40.4%) was slightly higher than that of SP1 (33.8%). The FT-IR spectra also showed characteristic band of carrageenan-like sulfated polysaccharides. Taken together the SPs are thought to be carrageenan-like sulfated galactan. The polysaccharides (SPs) from I. cordata exhibited weak antitumor activity against PC-3 (prostate cancer), HeLa (cervical cancer), and HT-29 (human colon adenocarcinoma). To our knowledge, this is the first data on biological activity of the Antarctic red seaweed I. cordata.
 Keywords
antarctic red seaweed;Iridaea cordata;sulfated polysaccharides;antitumor activity;
 Language
English
 Cited by
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