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The Effect of Petasites japonicus Extract on Hepatotoxicity in Rats
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 Title & Authors
The Effect of Petasites japonicus Extract on Hepatotoxicity in Rats
Park, Ji-Young;
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 Abstract
Petasites japonicus (Compositae) is a perennial herb which has been used as treatment of antitussive, expectorant, sedatives, paralysis, diurectics in folk remedies. The pharmacological studies of this natural drug have not yet estabilished. So, we examined anti-lipid peroxidative effects and liver protective effect on induced lipid peroxidation and hepatotoxicity in rats. In vivo liver lipid, MeOH Ex. revealed significant increase of anti-lipid peroxidative effects according to concentration dependently. In chemical parameters obtained from serum analysis, MeOH Ex. as a increase of medicine concentration (0.25 g/kg, 0.5 g/kg, 1.0 g/kg), GOT, GPT, AlP decreased. In 0.5 g/kg GPT administered group, there was relative in GOT, AlP. Cholesterol decreased in 1.0 g/kg and 1.0 g/kg administered group, BUN decreased relatively in 1.0 g/kg administered group.
 Keywords
Petasites japonicus;anti-lipid peroxidation;hepatotoxicity;
 Language
English
 Cited by
1.
족도리풀 뿌리의 메탄올엑스 분획이 마우스의 세포성 및 체액성 면역반응에 미치는 영향,박지영;

한국환경보건학회지, 2008. vol.34. 3, pp.213-218 crossref(new window)
2.
머위(Petasites japonicus) 엽병으로부터 항산화 물질의 분리 및 동정,김민영;이정현;황윤이;송경식;전미라;

한국식품영양과학회지, 2008. vol.37. 8, pp.979-984 crossref(new window)
3.
머위(Petasites japonicus)와 여주(Momordica charantia L.) 추출물의 MC3T3-E1 조골세포 증식 및 분화에 미치는 효과,지숙희;안도환;전미라;

한국식품영양과학회지, 2010. vol.39. 2, pp.203-209 crossref(new window)
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