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Effects of Gamdutang on Protection Against Accumulation of Cadmium in Rats
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 Title & Authors
Effects of Gamdutang on Protection Against Accumulation of Cadmium in Rats
Lee, In-Sook; Cho, Young-Chae;
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 Abstract
These experiments were conducted to determine the effects of Gamdutang on the accumulation of cadmium in the body of groups of rats that received an 8-week administration of 1.7, 3.4 and /g/day of cadmium, respectively, while the other groups of rats received an 8-week administration of a mixture of cadmium by concentration and Gamdutang. A comparative analysis of these groups was conducted in respect of weight, accumulated cadmium in blood and diverse organs and pathological findings from the kidneys. As for the cadmium accumulation in blood, livers, kidneys, and testis, with the lengthening of the experiment period, the cadmium and Gamdutang mixture-administered groups tended to have reduced accumulation levels compared with the groups exclusively administered cadmium. Histopathological observation of the kidneys, observed in the cadmium exclusively administered groups showed hemorrhagic necrosis in glomeruli, swelling of tubules, epithelial shedding and necrosis of tubules; however, only mild tissue lesions were observed in the cadmium and Gamdutang mixture-administered groups. Given the above results, Gamdutang is deemed to have the effects of reducing the accumulation of cadmium in blood, liver, and testis when low-concentration cadmium is administered to rats.
 Keywords
Cadmium;Accumulation;Blood;Liver;Kidney;Testis;Rat;
 Language
English
 Cited by
 References
1.
Sendelbach, L. E. and Klaassen, C. D. : Kidney synthesizes less metallothionein than liver in response to cadmium chloride and cadmium. metallothionein. Toxicology and Applied Pharmacology, 92, 95-102, 1988 crossref(new window)

2.
Hammond, P. B. and Foulkes, E. C. : Metal ion toxicity in man and animals. In ; H Siegel (ed), metal ions in biological systems. Vol. 20, Marcel Dekker, New York, p177, 1986

3.
Lee, J. W., Jang, B. K., Pack, J. A., Pack, J. Y., Kim, W. J. and Woo K. M. : The mechanism of the neurotoxicity induced by cadmium. Korean Journal of Environmental Toxicology, 19(3), 279-286, 2004

4.
Cho, Y. C. : In vitro magnetometry, LDH activity and apoptosis as indices of cytotoxicity in alveolar macrophages exposed to cadmium chloride. Korean Journal of Environmental Health, 26(4), 115-121, 2000

5.
Dudley, R. E., Svoboda, D. J. and Klaassen, C. D : Acute exposure to cadmium causes severe liver injury in rat. Toxicology and Applied Pharmacology, 65, 302, 1982 crossref(new window)

6.
Kim, E. J., Kim, S., Yang, E. J., Han, S. R., Kim, S. I. and Kim, W. S. : A study on the congenital anomalies induced by cadmium chloride. Korean Journal of Physical Anthropologists, 13(2), 239-251, 2000

7.
Webster, W. S. : Cadmium induced fetal growth retardation in the mouse. Archives of Environmental and Occupational Health, 32, 16-22, 1978

8.
Klassen, C. D., Amdur, M. O. and Doull, J. : Casaret and Doull's Toxicology, 3rd ed., Macmillan, p23-100, 1986

9.
Ando, M., Matsui, S., Jinno, H. and Takeda, M. : Urinary excretion of cyclic AMP in cadmiumintoxicated rats. Journal of Toxicology and Environmental Health, 27, 307-315, 1989 crossref(new window)

10.
Prasada Rao R. V. V., Jordan, S. A. and Bhatnagar, M. K. : Combined nephrotoxicity of methylmercury lead and cadmium in pekin ducks, metallothionein, metalinteractions, and histopathology. Journal of Toxicology and Environmental Health, 26, 327-348, 1989 crossref(new window)

11.
Hamer, D. H. : Metallothionein. Annual Review of Biochemistry, 55, 913-951, 1986 crossref(new window)

12.
Onosaka, S., Tanaka, K. and Cherian, M. G : Effects of cadmium and zinc on tissue of metallothionein. Journal of Environmental Health Perspectives, 54, 67-72, 1984 crossref(new window)

13.
Nomiyama, K. and Nomiyama, H. : Aggravated toxicities of cadmium chloride and mercury(II) chloride in zinc deficient rats. Acta Pharmacological Toxicology Supplement, 59(7), 75-78, 1986

14.
Ahokas, R. A., Dilts, P. V. and Lahaye, E. B. : Cadmium induced fetal growth retardation: Protective effect of excess dietary zinc. American Journal of Obstetrics and Gynecology, 136, 216-221, 1980

15.
Schroeder, H. A., Frost, D. V. and Balassa, J. J. : Essential trace metals in man. Selenium. Journal of Chronic Diseases, 23, 227-243, 1970 crossref(new window)

16.
Suh, E. S. and Lim, J. P. : Effects of Yukmijihwang- Tang on the Hepatic Microsomal Function of Cdpoisoned Rat. Korean Journal of Pharmacognosy, 30(3), 250, 1999

17.
Lee, S. D. : A Study on the preventive effect of Kamdoo decoction on the subacute lead toxicity in rats. Graduate School of Public Health Seoul National University, 1993

18.
Chung, S. H. : Effects of Glycyrrhizae Radix and Semen Glycine extraction the hepatic injuries induced by $CCl_4$ in rats. Graduate School of Public Health Chungnam National University, 1999

19.
Han, S. H. : Antitumor activity of Gamdutang aquaacupuncture solution. Graduate School of Oriental Medicine Dongguk University, 1999

20.
Committee for Translating Donguibogam into Korean : Donguibogam. Namsandang. 1994

21.
Rho, J. H., Han, C. K., Seong, K. S. and Lee, N. H. : Effects of pork on cadmium detoxification in rats. Korean Journal of the Food Science and Animal Resources, 25(4), 373-382, 2005

22.
Choi, S. I., Lee, J. H. and Lee, S. R.: Effect of Green tea beverage for the removal of cadmium and lead by animal experiments. Korean Journal of the Food Science and Technology, 26(6), 745-749, 1994

23.
Cantilena, L. R. and Klassen, C. D. : Decreased effectiveness of chelation theraphy with after acute cadmium poisoning. Toxicology and Applied Pharmacology 43, 173-180, 1982

24.
Combs, D. K., Goodrich, R. D. and Meiske, J. C. : Influence and dietary zinc of cadmium on hair and tissue mineral concentration in rat and goats. Journal of Animal Science, 56, 184-193, 1983

25.
Sharma, R. P, and Street, J. C. : Public health aspects of toxic heavy metals in animal feed. American Journal of Veterinary Medical Association, 177, 149-153, 1980

26.
Agarwal, A. K. : Metabolic alterations in liver and testes of adult and new born rats following cadmium administration. Bulletin of Environmental Contamination and Toxicology, 40, 569-575, 1988 crossref(new window)

27.
Dudley, R. E., Gammal, L. M. and Klaassen, C. D. : Cadmium-induced hepatic cadmium metallothionein in nephrotoxicity. Toxicology and Applied Pharmacology, 77, 414-426, 1985 crossref(new window)

28.
Kim, P. G. : Effects of Garlic Oil (diallyl disulfide)/Vitamin A (retinal acetate) on heat shock protein induction in cadmium treated rats. Journal of Food Hygiene and Safety, 13(2), 171-187, 1998

29.
Nishizumi, M. : Electron microscopic study of cadmium nephrotoxicity in the rat. Archives of Environmental and Occupational Health, 24, 215-225, 1972 crossref(new window)

30.
Jang, J. S. and Kwon, O. D., : Histopathological studies on the effect of Korean Safflower (Carthamus tinctorious L.) seed powder on cadmium poisoning in mice. Journal of Veterinary Clinical Medicine, 18(2), 116-123, 2001